3CSH

Crystal Structure of Glutathione Transferase Pi in complex with the Chlorambucil-Glutathione Conjugate

Summary for 3CSH

Entry DOI	10.2210/pdb3csh/pdb
Related	3CSI 3CSJ
Descriptor	Glutathione S-transferase P, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (8 entities in total)
Functional Keywords	transferase, glutathione, detoxification, chlorambucil
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P09211
Total number of polymer chains	2
Total formula weight	48855.46
Authors	Parker, L.J. (deposition date: 2008-04-09, release date: 2008-07-01, Last modification date: 2023-08-30)
Primary citation	Parker, L.J.,Ciccone, S.,Italiano, L.C.,Primavera, A.,Oakley, A.J.,Morton, C.J.,Hancock, N.C.,Bello, M.L.,Parker, M.W. The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants. J.Mol.Biol., 380:131-144, 2008 Cited by PubMed: 18511072 DOI: 10.1016/j.jmb.2008.04.066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation