PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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7UCD	Transcription factor FosB/JunD bZIP domain covalently modified with the cysteine-targeting alpha-haloketone compound Z2159931480 分子名称: 7-acetyl-4-methoxy-1-benzofuran-3(2H)-one, CHLORIDE ION, Protein fosB, ... 著者 Kumar, A, Machius, M.C, Rudenko, G. 登録日 2022-03-16 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Chemically targeting the redox switch in AP1 transcription factor Delta FOSB. Nucleic Acids Res., 50, 2022
1CJU	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG 分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENYLATE CYCLASE, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1999-04-16 公開日 1999-08-31 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
8FC8	Cryo-EM structure of the human TRPV4 in complex with GSK1016790A 分子名称: CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 著者 Kwon, D.H, Lee, S.-Y, Zhang, F. 登録日 2022-12-01 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
8FCA	Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate 分子名称: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4 著者 Kwon, D.H, Lee, S.-Y, Zhang, F. 登録日 2022-12-01 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
5N75	14-3-3 sigma in complex with TAZ pS89 peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Sijbesma, E, Leysen, S, Ottmann, C. 登録日 2017-02-19 公開日 2017-07-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
5N5R	14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV1 分子名称: 14-3-3 protein sigma, 2-azanyl-~{N}-(2,6-dimethylphenyl)-~{N}-propan-2-yl-ethanamide, CHLORIDE ION, ... 著者 Sijbesma, E, Leysen, S, Ottmann, C. 登録日 2017-02-14 公開日 2017-07-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
5OK9	CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with swapped phosphopeptides 分子名称: 14-3-3 protein sigma,Heat shock protein beta-6, DI(HYDROXYETHYL)ETHER 著者 Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. 登録日 2017-07-25 公開日 2017-10-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017
1CJV	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MG, AND ZN 分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1999-04-19 公開日 1999-08-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
5OEH	Molecular tweezers modulate 14-3-3 protein-protein interactions. 分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Bier, D, Ottmann, C. 登録日 2017-07-07 公開日 2017-07-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Molecular tweezers modulate 14-3-3 protein-protein interactions. Nat Chem, 5, 2013
7UG1	CDK2 liganded with para chloro ANS 分子名称: 1,2-ETHANEDIOL, 8-(4-chloroanilino)naphthalene-1-sulfonic acid, Cyclin-dependent kinase 2, ... 著者 Schonbrunn, E, Martin, M. 登録日 2022-03-23 公開日 2023-04-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Allosteric inhibitors of CDK2 To Be Published
7JPP	ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... 著者 Jaremko, M.J, Joshua-Tor, L. 登録日 2020-08-09 公開日 2020-09-09 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
5OKF	CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with self-bound phosphopeptides 分子名称: 14-3-3 protein sigma,Heat shock protein beta-6, CADMIUM ION 著者 Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. 登録日 2017-07-25 公開日 2017-10-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017
3JVL	Crystal structure of bromodomain 2 of mouse Brd4 分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Bromodomain-containing protein 4 著者 Vollmuth, F, Blankenfeldt, W, Geyer, M. 登録日 2009-09-17 公開日 2009-10-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009
1HN4	PROPHOSPHOLIPASE A2 DIMER COMPLEXED WITH MJ33, SULFATE, AND CALCIUM 分子名称: 1-HEXADECYL-3-TRIFLUOROETHYL-SN-GLYCERO-2-PHOSPHATE METHANE, CALCIUM ION, PROPHOSPHOLIPASE A2, ... 著者 Epstein, T.M, Pan, Y.H, Jain, M.K, Bahnson, B.J. 登録日 2000-12-06 公開日 2001-12-05 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The basis for k(cat) impairment in prophospholipase A(2) from the anion-assisted dimer structure. Biochemistry, 40, 2001
5OO0	Cdk2(WT) covalent adduct with D28 at C177 分子名称: Cyclin-dependent kinase 2, methyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate 著者 Craven, G, Morgan, R.M.L, Mann, D.J. 登録日 2017-08-04 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery. Angew. Chem. Int. Ed. Engl., 57, 2018
7V3U	Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... 著者 Cheng, J, Li, N, Huo, Y, Dang, S, Tye, B, Gao, N, Zhai, Y. 登録日 2021-08-11 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase. Nat Commun, 13, 2022
7V3V	Cryo-EM structure of MCM double hexamer bound with DDK in State I 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 7, DDK kinase regulatory subunit DBF4, ... 著者 Cheng, J, Li, N, Huo, Y, Dang, S, Tye, B, Gao, N, Zhai, Y. 登録日 2021-08-11 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase. Nat Commun, 13, 2022
8FF8	CRYSTAL STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 2-[(4-CYANOPHENYL)AMINO]-N-(4-PHENYLPYRIDIN-3-YL)PYRIMIDINE-4-CARBOXAMIDE 分子名称: 2-(4-cyanoanilino)-N-(4-phenylpyridin-3-yl)pyrimidine-4-carboxamide, Glycogen synthase kinase-3 beta 著者 Muckelbauer, J.K, Lewis, H.A. 登録日 2022-12-08 公開日 2023-06-07 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. J.Med.Chem., 66, 2023
5MR7	Crystal structure of the DBD domain of human Grhl2 分子名称: Grainyhead-like protein 2 homolog 著者 Schuetz, A, Ming, Q, Roske, Y, Heinemann, U. 登録日 2016-12-21 公開日 2018-01-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family. Nucleic Acids Res., 46, 2018
5OO1	Cdk2(F80C, C177A) covalent adduct with C37 at F80C 分子名称: Cyclin-dependent kinase 2, ~{N}-(4-pyrimidin-2-ylphenyl)propanamide 著者 Craven, G, Morgan, R.M.L, Mann, D.J. 登録日 2017-08-04 公開日 2018-08-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 High-throughput kinetic analysis for target-directed covalent ligand discovery To be published
7T9I	Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain, ... 著者 Faust, B, Cheng, Y, Manglik, A. 登録日 2021-12-19 公開日 2022-08-03 最終更新日 2022-10-05 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609, 2022
2GV5	crystal structure of Sfi1p/Cdc31p complex 分子名称: Cell division control protein 31, Sfi1p 著者 Li, S, Sandercock, A.M, Conduit, P.T, Robinson, C.V, Williams, R.L, Kilmartin, J.V. 登録日 2006-05-02 公開日 2006-06-27 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication. J.Cell Biol., 173, 2006
7JPS	ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3'), ... 著者 Jaremko, M.J, Joshua-Tor, L. 登録日 2020-08-09 公開日 2020-09-09 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JPR	ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... 著者 Jaremko, M.J, Joshua-Tor, L. 登録日 2020-08-09 公開日 2020-09-09 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
5OM0	CH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide around Ser640 分子名称: 14-3-3 protein sigma,Zinc finger protein GLI1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION 著者 Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. 登録日 2017-07-28 公開日 2017-10-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017

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