7UCD

Transcription factor FosB/JunD bZIP domain covalently modified with the cysteine-targeting alpha-haloketone compound Z2159931480

Summary for 7UCD

Entry DOI	10.2210/pdb7ucd/pdb
Descriptor	Protein fosB, Transcription factor jun-D, 7-acetyl-4-methoxy-1-benzofuran-3(2H)-one, ... (4 entities in total)
Functional Keywords	fosb, jund, redox switch, redox sensor, transcription factor, dna binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	16604.72
Authors	Kumar, A.,Machius, M.C.,Rudenko, G. (deposition date: 2022-03-16, release date: 2023-01-25, Last modification date: 2023-10-25)
Primary citation	Kumar, A.,Aglyamova, G.,Yim, Y.Y.,Bailey, A.O.,Lynch, H.M.,Powell, R.T.,Nguyen, N.D.,Rosenthal, Z.,Zhao, W.N.,Li, Y.,Chen, J.,Fan, S.,Lee, H.,Russell, W.K.,Stephan, C.,Robison, A.J.,Haggarty, S.J.,Nestler, E.J.,Zhou, J.,Machius, M.,Rudenko, G. Chemically targeting the redox switch in AP1 transcription factor Delta FOSB. Nucleic Acids Res., 50:9548-9567, 2022 Cited by PubMed: 36039764 DOI: 10.1093/nar/gkac710 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.21 Å)

Structure validation