5ZG9
 
 | | Crystal structure of MoSub1-ssDNA complex in phosphate buffer | | 分子名称: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*G)-3'), MoSub1, PHOSPHATE ION | | 著者 | Zhao, Y, Huang, J, Liu, H, Yi, L, Wang, S, Zhang, X, Liu, J. | | 登録日 | 2018-03-08 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | The effect of phosphate ion on the ssDNA binding mode of MoSub1, a Sub1/PC4 homolog from rice blast fungus.
Proteins, 87, 2019
|
|
4DBK
 | | Crystal structure of porcine pancreatic phospholipase A2 complexed with berberine | | 分子名称: | BERBERINE, CALCIUM ION, Phospholipase A2, ... | | 著者 | Naveen, C.D, Abhilash, J, Prasanth, G.K, Sadasivan, C, Haridas, M. | | 登録日 | 2012-01-16 | | 公開日 | 2012-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of porcine pancreatic phospholipase A2 complexed with berberine
To be Published
|
|
8URV
 | |
6AZJ
 | | Crystal Structure of human NAMPT in complex with NVP-LQN520 | | 分子名称: | (1S,2S)-N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide, Nicotinamide phosphoribosyltransferase | | 著者 | Weihofen, W.A, Thigale, S. | | 登録日 | 2017-09-11 | | 公開日 | 2018-09-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
To Be Published
|
|
6B75
 | | Crystal Structure of human NAMPT in complex with NVP-LOQ594 | | 分子名称: | 4-[(piperazin-1-yl)methyl]-N-{[4-({[(pyridin-3-yl)methyl]carbamoyl}amino)phenyl]methyl}benzamide, Nicotinamide phosphoribosyltransferase | | 著者 | Weihofen, W.A, Thigale, S. | | 登録日 | 2017-10-03 | | 公開日 | 2018-10-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
To Be Published
|
|
6ATH
 | | Cdk2/cyclin A/p27-KID-deltaC | | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, ... | | 著者 | White, S.W, Yun, M. | | 登録日 | 2017-08-29 | | 公開日 | 2018-09-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation.
Nat Commun, 10, 2019
|
|
5ZO6
 | |
7MJP
 | | Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Sung, M.W, Shyng, S.L. | | 登録日 | 2021-04-20 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7MJQ
 | | Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 8, ... | | 著者 | Sung, M.W, Shyng, S.L. | | 登録日 | 2021-04-20 | | 公開日 | 2021-10-13 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
5ZJR
 | | Structure of AbdB/Exd complex bound to a 'Magenta14' DNA sequence | | 分子名称: | DNA (5'-D(*GP*TP*CP*GP*TP*AP*AP*AP*TP*CP*AP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*AP*C)-3'), Homeobox protein abdominal-B, ... | | 著者 | Zeiske, T, Baburajendran, N, Kaczynska, A, Mann, R, Honig, B, Shapiro, L, Palmer, A.G. | | 登録日 | 2018-03-22 | | 公開日 | 2018-08-29 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | | 主引用文献 | Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.
Cell Rep, 24, 2018
|
|
6ATB
 | | Crystal Structure of human NAMPT in complex with NVP-LOD812 | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-N'-[(pyridin-3-yl)methyl]urea, ... | | 著者 | Weihofen, W.A, Thigale, S. | | 登録日 | 2017-08-28 | | 公開日 | 2018-09-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
To Be Published
|
|
3QZS
 | |
5ZJQ
 | | Structure of AbdB/Exd complex bound to a 'Red14' DNA sequence | | 分子名称: | DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*TP*TP*AP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*TP*AP*AP*AP*TP*CP*AP*TP*GP*C)-3'), Homeobox protein abdominal-B, ... | | 著者 | Baburajendran, N, Zeiske, T, Kaczynska, A, Mann, R, Honig, B, Shapiro, L, Palmer, A.G. | | 登録日 | 2018-03-22 | | 公開日 | 2018-08-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.443 Å) | | 主引用文献 | Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.
Cell Rep, 24, 2018
|
|
7MIT
 | | Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 1 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... | | 著者 | Sung, M.W, Shyng, S.L. | | 登録日 | 2021-04-17 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
1XCG
 | | Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF | | 分子名称: | Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | | 著者 | Derewenda, U, Oleksy, A, Stevenson, A.S, Korczynska, J, Dauter, Z, Somlyo, A.P, Otlewski, J, Somlyo, A.V, Derewenda, Z.S. | | 登録日 | 2004-09-01 | | 公開日 | 2004-12-14 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle
Structure, 12, 2004
|
|
7MJO
 | | Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 1 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... | | 著者 | Sung, M.W, Shyng, S.L. | | 登録日 | 2021-04-20 | | 公開日 | 2021-10-13 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
5Y38
 | | Crystal structure of C7orf59-HBXIP complex | | 分子名称: | Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5, SULFATE ION | | 著者 | Zhang, T, Ding, J. | | 登録日 | 2017-07-28 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Nat Commun, 8, 2017
|
|
5Y39
 | | Crystal structure of Ragulator complex (p18 76-145) | | 分子名称: | Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... | | 著者 | Zhang, T, Ding, J. | | 登録日 | 2017-07-28 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Nat Commun, 8, 2017
|
|
5YDE
 | | Crystal structure of a disease-related gene, hCDC73(1-111) | | 分子名称: | Parafibromin | | 著者 | Sun, W, Kuang, X.L, Liu, Y.P, Tian, L.F, Yan, X.X, Xu, W.Q. | | 登録日 | 2017-09-13 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.023 Å) | | 主引用文献 | Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome
Sci Rep, 7, 2017
|
|
7JVR
 | | Cryo-EM structure of Bromocriptine-bound dopamine receptor 2 in complex with Gi protein | | 分子名称: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | | 登録日 | 2020-08-22 | | 公開日 | 2021-02-24 | | 最終更新日 | 2021-03-31 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
|
|
7MZ5
 | |
6K5W
 | |
6BOE
 | | TBK1 in complex with amide-coupled tetrazole analog of amlexanox | | 分子名称: | 2-amino-5-oxo-7-(propan-2-yl)-N-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide, Serine/threonine-protein kinase TBK1 | | 著者 | Beyett, T.S, Tesmer, J.J.G. | | 登録日 | 2017-11-19 | | 公開日 | 2018-09-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.598 Å) | | 主引用文献 | Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
|
|
4CY1
 | | Crystal structure of the KANSL1-WDR5 complex. | | 分子名称: | GLYCEROL, KAT8 REGULATORY NSL COMPLEX SUBUNIT 1, WD REPEAT-CONTAINING PROTEIN 5 | | 著者 | Dias, J, Brettschneider, J, Cusack, S, Kadlec, J. | | 登録日 | 2014-04-09 | | 公開日 | 2014-05-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex.
Genes Dev., 28, 2014
|
|
7N0A
 | | Structure of Human Leukaemia Inhibitory Factor with Fab MSC1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Leukemia inhibitory factor, ... | | 著者 | Raman, S, Bosch, A, Fransson, J, Julien, J.P. | | 登録日 | 2021-05-25 | | 公開日 | 2022-06-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment.
Clin.Cancer Res., 29, 2023
|
|
