6OZU
 
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7D8B
 | | Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways | | 分子名称: | Eukaryotic translation initiation factor 4E, VH-S4 | | 著者 | Frosi, Y, Lin, Y.C, Jiang, S, Brown, C.J. | | 登録日 | 2020-10-07 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022
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6O9Z
 | | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens | | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | | 著者 | Nguyen, H.C, Kenner, L.R, Frost, A.S. | | 登録日 | 2019-03-15 | | 公開日 | 2019-05-15 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364, 2019
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6Q84
 | | Crystal structure of RanGTP-Pdr6-eIF5A export complex | | 分子名称: | Eukaryotic translation initiation factor 5A-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Aksu, M, Trakhanov, S, Vera-Rodriguez, A, Gorlich, D. | | 登録日 | 2018-12-14 | | 公開日 | 2019-05-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122.
J.Cell Biol., 218, 2019
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6QG1
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model 2) | | 分子名称: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | 著者 | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | 登録日 | 2019-01-10 | | 公開日 | 2019-06-26 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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5EKV
 | | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | | 分子名称: | 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1 | | 著者 | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | | 登録日 | 2015-11-04 | | 公開日 | 2016-09-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | | 主引用文献 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Eur.J.Med.Chem., 124, 2016
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5EHC
 | | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | | 分子名称: | 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E | | 著者 | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | | 登録日 | 2015-10-28 | | 公開日 | 2016-09-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Eur.J.Med.Chem., 124, 2016
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2IJA
 | | Human N-acetyltransferase 1 F125S mutant | | 分子名称: | ACETAMIDE, Arylamine N-acetyltransferase 1, SODIUM ION, ... | | 著者 | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Grant, D.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2006-09-29 | | 公開日 | 2006-11-28 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | | 主引用文献 | The Crystal Structure of Human N-acetyltransferase 1 mutant, F125S
To be Published
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4F02
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6FEC
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8INK
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8IPX
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8IE3
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8INE
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8IPY
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8IDY
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8IPD
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8IDT
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8INF
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5T46
 | | Crystal structure of the human eIF4E-eIF4G complex | | 分子名称: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E, ... | | 著者 | Gruener, S, Peter, D, Weber, R, Wohlbold, L, Chung, M.-Y, Weichenrieder, O, Valkov, E, Igreja, C, Izaurralde, E. | | 登録日 | 2016-08-29 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
Mol.Cell, 64, 2016
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7XTP
 | | eIF4E in Complex with a Disulphide-Free Autonomous VH Domain | | 分子名称: | Eukaryotic translation initiation factor 4E, VH-S4ss, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE | | 著者 | Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C. | | 登録日 | 2022-05-17 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.828 Å) | | 主引用文献 | Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022
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5T48
 | | Crystal structure of the D. melanogaster eIF4E-eIF4G complex without lateral contact | | 分子名称: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4G, ... | | 著者 | Gruener, S, Peter, D, Weber, R, Wohlbold, L, Chung, M.-Y, Weichenrieder, O, Valkov, E, Igreja, C, Izaurralde, E. | | 登録日 | 2016-08-29 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
Mol.Cell, 64, 2016
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3ISD
 | | Ternary complex of human DNA polymerase beta with an abasic site (THF): DAPCPP mismatch | | 分子名称: | 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, 5'-D(*CP*CP*GP*AP*CP*(3DR)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', ... | | 著者 | Beard, W.A, Shock, D.D, Batra, V.K, Pedersen, L.C, Wilson, S.H. | | 登録日 | 2009-08-25 | | 公開日 | 2009-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | DNA polymerase beta substrate specificity: side chain modulation of the "A-rule".
J.Biol.Chem., 284, 2009
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8HUJ
 | | Cryo-EM structure of the J-K-St region of EMCV IRES in complex with eIF4G-HEAT1 and eIF4A | | 分子名称: | Eukaryotic initiation factor 4A-I, Eukaryotic translation initiation factor 4 gamma 1, IRES RNA (J-K-St), ... | | 著者 | Suzuki, H, Fujiyoshi, Y, Imai, S, Shimada, I. | | 登録日 | 2022-12-24 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | | 主引用文献 | Dynamically regulated two-site interaction of viral RNA to capture host translation initiation factor.
Nat Commun, 14, 2023
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5J2K
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