Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens

Summary for 6O9Z

EMDB information0664
DescriptorTranslation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... (6 entities in total)
Functional Keywordseukaryotic translation initiation factor 2b, eukaryotic translation initiation factor 2, translation
Biological sourceHomo sapiens (Human)
Total number of polymer chains12
Total molecular weight600795.66
Nguyen, H.C.,Kenner, L.R.,Frost, A.S. (deposition date: 2019-03-15, release date: 2019-05-15, Last modification date: 2019-12-18)
Primary citation
Kenner, L.R.,Anand, A.A.,Nguyen, H.C.,Myasnikov, A.G.,Klose, C.J.,McGeever, L.A.,Tsai, J.C.,Miller-Vedam, L.E.,Walter, P.,Frost, A.
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364:491-495, 2019
PubMed: 31048491 (PDB entries with the same primary citation)
DOI: 10.1126/science.aaw2922
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers120 0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload