6FDU
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![BU of 6fdu by Molmil](/molmil-images/mine/6fdu) | Structure of Chlamydia trachomatis effector protein Cdu1 bound to Compound 3 | 分子名称: | (2~{S},3~{S})-2-[[(2~{S})-2-[3,5-bis(chloranyl)phenyl]-2-(dimethylamino)ethanoyl]amino]-~{N}-[[2-(iminomethyl)pyrimidin-4-yl]methyl]-3-methyl-pentanamide, CHLORIDE ION, Deubiquitinase and deneddylase Dub1 | 著者 | Ramirez, Y, Kisker, C, Altmann, E. | 登録日 | 2017-12-26 | 公開日 | 2018-08-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis. ChemMedChem, 13, 2018
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6FDQ
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4RIS
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![BU of 4ris by Molmil](/molmil-images/mine/4ris) | Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk | 分子名称: | CH58-UA Fab heavy chain, CH58-UA Fab light chain, Envelope glycoprotein | 著者 | Nicely, N.I, Wiehe, K, Kepler, T.B, Jaeger, F.H, Dennison, S.M, Liao, H.-X, Alam, S.M, Hwang, K.-K, Bonsignori, M, Rerks-Ngarm, S, Nitayaphan, S, Pitisuttithum, P, Kaewkungwal, J, Robb, M.L, O'Connell, R.J, Michael, N.L, Kim, J.H, Haynes, B.F. | 登録日 | 2014-10-07 | 公開日 | 2015-08-12 | 最終更新日 | 2015-09-02 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee. EBioMedicine, 2, 2015
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4RIR
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![BU of 4rir by Molmil](/molmil-images/mine/4rir) | Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk | 分子名称: | CH58-UA Fab heavy chain, CH58-UA Fab light chain | 著者 | Nicely, N.I, Wiehe, K, Kepler, T.B, Jaeger, F.H, Dennison, S.M, Liao, H.-X, Alam, S.M, Hwang, K.-K, Bonsignori, M, Rerks-Ngarm, S, Nitayaphan, S, Pitisuttithum, P, Kaewkungwal, J, Robb, M.L, O'Connell, R.J, Michael, N.L, Kim, J.H, Haynes, B.F. | 登録日 | 2014-10-07 | 公開日 | 2015-08-12 | 最終更新日 | 2015-09-02 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee. EBioMedicine, 2, 2015
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7E4U
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![BU of 7e4u by Molmil](/molmil-images/mine/7e4u) | |
4NEW
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![BU of 4new by Molmil](/molmil-images/mine/4new) | Crystal structure of Trypanothione Reductase from Trypanosoma cruzi in complex with inhibitor EP127 (5-{5-[1-(PYRROLIDIN-1-YL)CYCLOHEXYL]-1,3-THIAZOL-2-YL}-1H-INDOLE) | 分子名称: | 5-{5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl}-1H-indole, FLAVIN-ADENINE DINUCLEOTIDE, Trypanothione reductase, ... | 著者 | Persch, E, Bryson, S, Pai, E.F, Krauth-Siegel, R.L, Diederich, F. | 登録日 | 2013-10-30 | 公開日 | 2014-05-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase. Chemmedchem, 9, 2014
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4NEV
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![BU of 4nev by Molmil](/molmil-images/mine/4nev) | Crystal structure of Trypanothione Reductase from Trypanosoma brucei in complex with inhibitor EP127 (5-{5-[1-(PYRROLIDIN-1-YL)CYCLOHEXYL]-1,3-THIAZOL-2-YL}-1H-INDOLE) | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-{5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl}-1H-indole, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Persch, E, Bryson, S, Pai, E.F, Krauth-Siegel, R.L, Diederich, F. | 登録日 | 2013-10-30 | 公開日 | 2014-05-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase. Chemmedchem, 9, 2014
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2UYL
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![BU of 2uyl by Molmil](/molmil-images/mine/2uyl) | Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1 | 分子名称: | MONOCLONAL ANTIBODY F-22-30 | 著者 | Ahmed, F, Haouz, A, Nato, F, Fournier, J.M, Alzari, P.M. | 登録日 | 2007-04-10 | 公開日 | 2008-05-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of a Monoclonal Antibody Directed Against an Antigenic Determinant Common to Ogawa and Inaba Serotypes of Vibrio Cholerae O1. Proteins, 70, 2008
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2V2V
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![BU of 2v2v by Molmil](/molmil-images/mine/2v2v) | IspE in complex with ligand | 分子名称: | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, 5'-[(1H-BENZIMIDAZOL-2-YLACETYL)AMINO]-5'-DEOXYCYTIDINE, BROMIDE ION, ... | 著者 | Alphey, M.S, Hunter, W.N. | 登録日 | 2007-06-07 | 公開日 | 2007-06-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis. Chemmedchem, 3, 2008
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2V2Q
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![BU of 2v2q by Molmil](/molmil-images/mine/2v2q) | IspE in complex with ligand | 分子名称: | 4-AMINO-1-(5-{[3-(1H-BENZIMIDAZOL-2-YL)PROPANOYL]AMINO}-5-DEOXY-ALPHA-L-LYXOFURANOSYL)PYRIMIDIN-2(1H)-ONE, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, BROMIDE ION, ... | 著者 | Alphey, M.S, Hunter, W.N. | 登録日 | 2007-06-06 | 公開日 | 2007-06-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis. Chemmedchem, 3, 2008
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2GGF
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![BU of 2ggf by Molmil](/molmil-images/mine/2ggf) | Solution structure of the MA3 domain of human Programmed cell death 4 | 分子名称: | Programmed cell death 4, isoform 1 | 著者 | Nagata, T, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2006-03-24 | 公開日 | 2007-04-24 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the MA3 domain of human Programmed cell death 4 To be Published
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2JWQ
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![BU of 2jwq by Molmil](/molmil-images/mine/2jwq) | G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study | 分子名称: | DNA (5'-D(*DTP*DTP*DAP*DGP*DGP*DGP*DT)-3'), N,N'-(dibenzo[b,j][1,7]phenanthroline-2,10-diyldimethanediyl)dipropan-1-amine | 著者 | Hounsou, C, Guittat, L, Monchaud, D, Jourdan, M, Saettel, N, Mergny, J.L, Teulade-Fichou, M. | 登録日 | 2007-10-23 | 公開日 | 2008-03-25 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study ChemMedChem, 2, 2007
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3GCM
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2NUH
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![BU of 2nuh by Molmil](/molmil-images/mine/2nuh) | |
4INB
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![BU of 4inb by Molmil](/molmil-images/mine/4inb) | |
3GKQ
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2HRC
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![BU of 2hrc by Molmil](/molmil-images/mine/2hrc) | 1.7 angstrom structure of human ferrochelatase variant R115L | 分子名称: | CHLORIDE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Medlock, A, Swartz, L, Dailey, T.A, Dailey, H.A, Lanzilotta, W.N. | 登録日 | 2006-07-20 | 公開日 | 2007-03-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Substrate interactions with human ferrochelatase Proc.Natl.Acad.Sci.Usa, 104, 2007
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3HCO
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![BU of 3hco by Molmil](/molmil-images/mine/3hco) | Human ferrochelatase with Cd and protoporphyrin IX bound | 分子名称: | BICARBONATE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | 登録日 | 2009-05-06 | 公開日 | 2009-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Product release rather than chelation determines metal specificity for ferrochelatase. J.Mol.Biol., 393, 2009
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3GME
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![BU of 3gme by Molmil](/molmil-images/mine/3gme) | |
3GLL
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![BU of 3gll by Molmil](/molmil-images/mine/3gll) | |
3HCR
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![BU of 3hcr by Molmil](/molmil-images/mine/3hcr) | Human Ferrochelatase with deuteroporphyrin and Ni Bound | 分子名称: | CHLORIDE ION, CHOLIC ACID, FE(III) DEUTEROPORPHYRIN IX, ... | 著者 | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | 登録日 | 2009-05-06 | 公開日 | 2009-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Product release rather than chelation determines metal specificity for ferrochelatase. J.Mol.Biol., 393, 2009
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3HCN
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![BU of 3hcn by Molmil](/molmil-images/mine/3hcn) | Hg and protoporphyrin bound Human Ferrochelatase | 分子名称: | BICARBONATE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | 登録日 | 2009-05-06 | 公開日 | 2009-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Product release rather than chelation determines metal specificity for ferrochelatase. J.Mol.Biol., 393, 2009
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3HCP
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![BU of 3hcp by Molmil](/molmil-images/mine/3hcp) | Human ferrochelatase with Mn and deuteroporphyrin bound | 分子名称: | CHOLIC ACID, FE(III) DEUTEROPORPHYRIN IX, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | 登録日 | 2009-05-06 | 公開日 | 2009-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Product release rather than chelation determines metal specificity for ferrochelatase. J.Mol.Biol., 393, 2009
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7MBO
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![BU of 7mbo by Molmil](/molmil-images/mine/7mbo) | FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR Milvexian (BMS-986177), IUPAC NAME:(6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6- oxopyrimidin-1(6H)-yl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-15,11- (metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIa light chain, Milvexian | 著者 | Sheriff, S. | 登録日 | 2021-04-01 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (0.924 Å) | 主引用文献 | Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy. J.Med.Chem., 65, 2022
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4U4S
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![BU of 4u4s by Molmil](/molmil-images/mine/4u4s) | Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM25 at 1.90 A resolution. | 分子名称: | 4-ethyl-3,4-dihydro-2H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide, ACETATE ION, CHLORIDE ION, ... | 著者 | Noerholm, A.B, Deva, T, Frydenvang, K, Kastrup, J.S. | 登録日 | 2014-07-24 | 公開日 | 2014-11-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. J.Med.Chem., 57, 2014
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