3HCO

Human ferrochelatase with Cd and protoporphyrin IX bound

Summary for 3HCO

• Entry DOI: 10.2210/pdb3hco/pdb
• Related: 3HCN 3HCP 3HCR
• Descriptor: Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, ... (9 entities in total)
• Functional Keywords: ferrochelatase, metal selectivity, disease mutation, heme biosynthesis, iron, iron-sulfur, lyase, membrane, metal-binding, mitochondrion, mitochondrion inner membrane, porphyrin biosynthesis, transit peptide
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86032.10

Authors

Medlock, A.E.,Dailey, H.A.,Lanzilotta, W.N. (deposition date: 2009-05-06, release date: 2009-11-10, Last modification date: 2024-02-21)

• Primary citation: Medlock, A.E.,Carter, M.,Dailey, T.A.,Dailey, H.A.,Lanzilotta, W.N.; Product release rather than chelation determines metal specificity for ferrochelatase.; J.Mol.Biol., 393:308-319, 2009; PubMed: 19703464; DOI: 10.1016/j.jmb.2009.08.042

Experimental method

X-RAY DIFFRACTION (1.8 Å)