2V2V

IspE in complex with ligand

Summary for 2V2V

• Entry DOI: 10.2210/pdb2v2v/pdb
• Related: 2V2Q 2V2Z 2V34 2V8P 2VF3
• Descriptor: 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, SULFATE ION, GLYCEROL, ... (6 entities in total)
• Functional Keywords: transferase, 4-diphosphocytidyl-2c-methyl-d- erythritol, aquifex aeolicus, nucleotide-binding, isoprene biosynthesis, kinase, atp-binding, non-mevalonate
• Biological source: AQUIFEX AEOLICUS
• Total number of polymer chains: 2
• Total formula weight: 62397.36

Authors

Alphey, M.S.,Hunter, W.N. (deposition date: 2007-06-07, release date: 2007-06-19, Last modification date: 2011-07-13)

• Primary citation: Crane, C.M.,Hirsch, A.K.,Alphey, M.S.,Sgraja, T.,Lauw, S.,Illarionova, V.,Rohdich, F.,Eisenreich, W.,Hunter, W.N.,Bacher, A.,Diederich, F.; Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis.; Chemmedchem, 3:91-, 2008; PubMed: 18033714; DOI: 10.1002/CMDC.200700208

Experimental method

X-RAY DIFFRACTION (2.4 Å)