3HCN

Hg and protoporphyrin bound Human Ferrochelatase

Summary for 3HCN

Entry DOI	10.2210/pdb3hcn/pdb
Related	3HCO 3HCP 3HCR
Descriptor	Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, CHOLIC ACID, ... (9 entities in total)
Functional Keywords	ferrochelatase, metal selectivity, disease mutation, heme biosynthesis, iron, iron-sulfur, lyase, membrane, metal-binding, mitochondrion, mitochondrion inner membrane, porphyrin biosynthesis, transit peptide
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side: P22830
Total number of polymer chains	2
Total formula weight	86128.16
Authors	Medlock, A.E.,Dailey, H.A.,Lanzilotta, W.N. (deposition date: 2009-05-06, release date: 2009-11-10, Last modification date: 2024-02-21)
Primary citation	Medlock, A.E.,Carter, M.,Dailey, T.A.,Dailey, H.A.,Lanzilotta, W.N. Product release rather than chelation determines metal specificity for ferrochelatase. J.Mol.Biol., 393:308-319, 2009 Cited by PubMed: 19703464 DOI: 10.1016/j.jmb.2009.08.042 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation