7QXW
| Proteasome-ZFAND5 Complex Z+D state | 分子名称: | 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-27 | 公開日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
|
|
7QYA
| Proteasome-ZFAND5 Complex Z-B state | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-27 | 公開日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
|
|
5VGZ
| Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | 分子名称: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | 著者 | Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | 登録日 | 2017-04-12 | 公開日 | 2017-08-23 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
|
|
1JPZ
| Crystal structure of a complex of the heme domain of P450BM-3 with N-Palmitoylglycine | 分子名称: | BIFUNCTIONAL P-450:NADPH-P450 REDUCTASE, N-PALMITOYLGLYCINE, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Haines, D.C, Tomchick, D.R, Machius, M, Peterson, J.A. | 登録日 | 2001-08-03 | 公開日 | 2001-11-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Pivotal role of water in the mechanism of P450BM-3. Biochemistry, 40, 2001
|
|
5VC0
| |
5VCE
| |
5VFS
| Nucleotide-Driven Triple-State Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 12, ... | 著者 | Zhu, Y, Wang, W.L, Yu, D, Ouyang, Q, Lu, Y, Mao, Y. | 登録日 | 2017-04-09 | 公開日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome. Nat Commun, 9, 2018
|
|
5VHS
| Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | 分子名称: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | 著者 | Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | 登録日 | 2017-04-13 | 公開日 | 2017-08-23 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (8.8 Å) | 主引用文献 | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
|
|
5VHF
| Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | 分子名称: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 10, ... | 著者 | Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | 登録日 | 2017-04-13 | 公開日 | 2017-08-23 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
|
|
5VHH
| Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | 分子名称: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 10, ... | 著者 | Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | 登録日 | 2017-04-13 | 公開日 | 2017-08-23 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
|
|
5VHI
| Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | 分子名称: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 10, ... | 著者 | Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | 登録日 | 2017-04-13 | 公開日 | 2017-08-23 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
|
|
5VCD
| |
8PWA
| Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA4) | 分子名称: | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7~{H}-purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid, ACETATE ION, MAGNESIUM ION, ... | 著者 | Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A. | 登録日 | 2023-07-19 | 公開日 | 2023-11-08 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12, 2024
|
|
8PWB
| Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA6) | 分子名称: | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(7~{H}-purin-6-ylcarbamoyl)amino]-2-azanyl-butanoic acid, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | 著者 | Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A. | 登録日 | 2023-07-19 | 公開日 | 2023-11-08 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12, 2024
|
|
8PW9
| Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA1) | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[2-[[9-[(2~{R},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethylamino]methyl]oxolane-3,4-diol, ACETATE ION, MAGNESIUM ION, ... | 著者 | Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A. | 登録日 | 2023-07-19 | 公開日 | 2023-11-08 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12, 2024
|
|
5VCG
| |
6EPC
| Ground state 26S proteasome (GS2) | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ... | 著者 | Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R. | 登録日 | 2017-10-11 | 公開日 | 2018-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (12.3 Å) | 主引用文献 | In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell, 172, 2018
|
|
5VFP
| Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 12, ... | 著者 | Zhu, Y, Wang, W.L, Yu, D, Ouyang, Q, Lu, Y, Mao, Y. | 登録日 | 2017-04-09 | 公開日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome. Nat Commun, 9, 2018
|
|
7UV9
| KDM2A-nucleosome structure stabilized by H3K36C-UNC8015 covalent conjugate | 分子名称: | DNA (185-MER), FE (III) ION, Histone H2A type 1, ... | 著者 | Spangler, C.J, Skrajna, A, Foley, C.A, Budziszewski, G.R, Azzam, D.N, James, L.I, Frye, S.V, McGinty, R.K. | 登録日 | 2022-04-29 | 公開日 | 2023-02-22 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis of paralog-specific KDM2A/B nucleosome recognition. Nat.Chem.Biol., 19, 2023
|
|
7UIG
| Mediator-PIC Early (Mediator A) | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... | 著者 | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | 登録日 | 2022-03-29 | 公開日 | 2023-02-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol.Cell, 83, 2023
|
|
5VFR
| Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 12, ... | 著者 | Zhu, Y, Wang, W.L, Yu, D, Ouyang, Q, Lu, Y, Mao, Y. | 登録日 | 2017-04-09 | 公開日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome. Nat Commun, 9, 2018
|
|
6CYK
| CTX-M-14 N106S mutant | 分子名称: | ACETATE ION, Beta-lactamase | 著者 | Patel, M.P, Hu, L, Sankaran, B, Brown, C, Prasad, B.V.V, Palzkill, T. | 登録日 | 2018-04-06 | 公開日 | 2018-10-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Synergistic effects of functionally distinct substitutions in beta-lactamase variants shed light on the evolution of bacterial drug resistance. J. Biol. Chem., 293, 2018
|
|
8S5N
| RNA polymerase II core initially transcribing complex with an ordered RNA of 12 nt | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. | 登録日 | 2024-02-24 | 公開日 | 2024-04-10 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
|
|
4L8M
| Human p38 MAP kinase in complex with a Dibenzoxepinone | 分子名称: | Mitogen-activated protein kinase 14, N-[2-fluoro-5-({9-[2-(morpholin-4-yl)ethoxy]-11-oxo-6,11-dihydrodibenzo[b,e]oxepin-3-yl}amino)phenyl]benzamide, octyl beta-D-glucopyranoside | 著者 | Richters, A, Mayer-Wrangowski, S.C, Gruetter, C, Rauh, D. | 登録日 | 2013-06-17 | 公開日 | 2013-10-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood. J.Med.Chem., 56, 2013
|
|
5VFQ
| Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 12, ... | 著者 | Zhu, Y, Wang, W.L, Yu, D, Ouyang, Q, Lu, Y, Mao, Y. | 登録日 | 2017-04-09 | 公開日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome. Nat Commun, 9, 2018
|
|