8PWA

Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA4)

Summary for 8PWA

• Entry DOI: 10.2210/pdb8pwa/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7~{H}-purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid, ... (6 entities in total)
• Functional Keywords: mettl3, bisubstrate, complex, m6a, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 60322.96

Authors

Bedi, R.K.,Etheve-Quelquejeu, M.,Caflisch, A. (deposition date: 2023-07-19, release date: 2023-11-08, Last modification date: 2024-03-27)

• Primary citation: Corbeski, I.,Vargas-Rosales, P.A.,Bedi, R.K.,Deng, J.,Coelho, D.,Braud, E.,Iannazzo, L.,Li, Y.,Huang, D.,Etheve-Quelquejeu, M.,Cui, Q.,Caflisch, A.; The catalytic mechanism of the RNA methyltransferase METTL3.; Elife, 12:-, 2024; PubMed: 38470714; DOI: 10.7554/eLife.92537

Experimental method

X-RAY DIFFRACTION (2.1 Å)