8PW9

Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA1)

Summary for 8PW9

Entry DOI	10.2210/pdb8pw9/pdb
Descriptor	N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[2-[[9-[(2~{R},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethylamino]methyl]oxolane-3,4-diol, ... (6 entities in total)
Functional Keywords	mettl3, bisubstrate, complex, m6a, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	60207.83
Authors	Bedi, R.K.,Etheve-Quelquejeu, M.,Caflisch, A. (deposition date: 2023-07-19, release date: 2023-11-08, Last modification date: 2024-03-27)
Primary citation	Corbeski, I.,Vargas-Rosales, P.A.,Bedi, R.K.,Deng, J.,Coelho, D.,Braud, E.,Iannazzo, L.,Li, Y.,Huang, D.,Etheve-Quelquejeu, M.,Cui, Q.,Caflisch, A. The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12:-, 2024 Cited by PubMed: 38470714 DOI: 10.7554/eLife.92537 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation