6ZZ6
 
 | | Cryo-EM structure of S.cerevisiae cohesin-Scc2-DNA complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (34-MER), MAGNESIUM ION, ... | | 著者 | Lee, B.-G, Gonzalez Llamazares, A, Collier, J, Nasmyth, K.A, Lowe, J. | | 登録日 | 2020-08-04 | | 公開日 | 2020-09-30 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3.
Elife, 9, 2020
|
|
6UCI
 | | Transcription factor DeltaFosB bZIP domain self-assembly, oxidized form | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Protein fosB | | 著者 | Yin, Z, Machius, M, Rudenko, G. | | 登録日 | 2019-09-16 | | 公開日 | 2020-01-15 | | 最終更新日 | 2020-07-01 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Self-assembly of the bZIP transcription factor Delta FosB.
Curr Res Struct Biol, 2, 2020
|
|
7RA5
 | | CDK2 IN COMPLEX WITH COMPOUND 4 | | 分子名称: | 4-[7-(methanesulfonyl)-1H-indol-3-yl]-N-[(3S)-piperidin-3-yl]-5-(trifluoromethyl)pyrimidin-2-amine, Cyclin-dependent kinase 2 | | 著者 | Marineau, J.J, Malojcic, G. | | 登録日 | 2021-06-30 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7.
J.Med.Chem., 65, 2022
|
|
4F3L
 | | Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex | | 分子名称: | BMAL1b, Circadian locomoter output cycles protein kaput | | 著者 | Huang, N, Chelliah, Y, Shan, Y, Taylor, C, Yoo, S, Partch, C, Green, C.B, Zhang, H, Takahashi, J. | | 登録日 | 2012-05-09 | | 公開日 | 2012-06-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.268 Å) | | 主引用文献 | Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science, 337, 2012
|
|
6HGO
 | | Crystal Structure of human IL-17F | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17F, ... | | 著者 | Rondeau, J.M, Goepfert, A. | | 登録日 | 2018-08-23 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
|
|
4N7Y
 | | Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS | | 分子名称: | 14-3-3 protein zeta/delta, Exoenzyme S | | 著者 | Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. | | 登録日 | 2013-10-16 | | 公開日 | 2014-02-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.
Angew.Chem.Int.Ed.Engl., 53, 2014
|
|
1O7Y
 | | Crystal structure of IP-10 M-form | | 分子名称: | SMALL INDUCIBLE CYTOKINE B10, SULFATE ION | | 著者 | Swaminathan, G.J, Holloway, D.E, Papageorgiou, A.C, Acharya, K.R. | | 登録日 | 2002-11-20 | | 公開日 | 2003-05-08 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal Structures of Oligomeric Forms of the Ip-10/Cxcl10 Chemokine
Structure, 11, 2003
|
|
6CU8
 | | Alpha Synuclein fibril formed by full length protein - Twister Polymorph | | 分子名称: | Alpha-synuclein | | 著者 | Li, B, Hatami, A, Ge, P, Murray, K.A, Sheth, P, Zhang, M, Nair, G, Sawaya, M.R, Zhu, C, Broad, M, Shin, W.S, Ye, S, John, V, Eisenberg, D.S, Zhou, Z.H, Jiang, L. | | 登録日 | 2018-03-23 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel.
Nat Commun, 9, 2018
|
|
7PZC
 | | Cryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3 | | 分子名称: | 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | | 著者 | Hochheiser, I.V, Pilsl, M, Hagelueken, G, Engel, C, Geyer, M. | | 登録日 | 2021-10-12 | | 公開日 | 2022-01-26 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.
Nature, 604, 2022
|
|
5D1C
 | | Crystal structure of D233G-Y306F HDAC8 in complex with a tetrapeptide substrate | | 分子名称: | GLYCEROL, HDAC8 Fluor de Lys tetrapeptide substrate, Histone deacetylase 8, ... | | 著者 | Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | | 登録日 | 2015-08-04 | | 公開日 | 2015-10-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.422 Å) | | 主引用文献 | Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
|
|
7ZIT
 | |
2NXP
 | |
6CU7
 | | Alpha Synuclein fibril formed by full length protein - Rod Polymorph | | 分子名称: | Alpha-synuclein | | 著者 | Li, B, Hatami, A, Ge, P, Murray, K.A, Sheth, P, Zhang, M, Nair, G, Sawaya, M.R, Zhu, C, Broad, M, Shin, W.S, Ye, S, John, V, Eisenberg, D.S, Zhou, Z.H, Jiang, L. | | 登録日 | 2018-03-23 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel.
Nat Commun, 9, 2018
|
|
5EGO
 | | HOXB13-MEIS1 heterodimer bound to methylated DNA | | 分子名称: | DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | | 著者 | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | | 登録日 | 2015-10-27 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356, 2017
|
|
5EGG
 | |
5EG0
 | | HOXB13-MEIS1 heterodimer bound to DNA | | 分子名称: | DNA (5'-D(*CP*CP*TP*CP*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | | 著者 | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | | 登録日 | 2015-10-26 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.101 Å) | | 主引用文献 | Molecular basis of recognition of two distinct DNA sequences by a single transcription factor
To Be Published
|
|
5EGS
 | | Human PRMT6 with bound fragment-type inhibitor | | 分子名称: | 2-[4-(phenylmethyl)piperidin-1-yl]ethanamine, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Steuber, H, Egner, U, Kania, J, Wu, H, Brown, P.J. | | 登録日 | 2015-10-27 | | 公開日 | 2016-02-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
J.Med.Chem., 59, 2016
|
|
7KKU
 | | X-ray Counterpart to Neutron Structure of Oxidized Human MnSOD | | 分子名称: | MANGANESE (III) ION, PHOSPHATE ION, Superoxide dismutase [Mn], ... | | 著者 | Azadmanesh, J, Lutz, W.E, Coates, L, Weiss, K.L, Borgstahl, G.E.O. | | 登録日 | 2020-10-28 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase.
Nat Commun, 12, 2021
|
|
7KKS
 | | Neutron structure of Oxidized Human MnSOD | | 分子名称: | MANGANESE (III) ION, Superoxide dismutase [Mn], mitochondrial | | 著者 | Azadmanesh, J, Lutz, W.E, Coates, L, Weiss, K.L, Borgstahl, G.E.O. | | 登録日 | 2020-10-28 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | NEUTRON DIFFRACTION (2.2 Å) | | 主引用文献 | Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase.
Nat Commun, 12, 2021
|
|
7SHK
 | | Structure of Xenopus laevis CRL2Lrr1 (State 1) | | 分子名称: | CULLIN_2 domain-containing protein, Elongin-C, Lrr1, ... | | 著者 | Zhou, H, Brown, A. | | 登録日 | 2021-10-09 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates.
Nucleic Acids Res., 49, 2021
|
|
7SHL
 | | Structure of Xenopus laevis CRL2Lrr1 (State 2) | | 分子名称: | CULLIN_2 domain-containing protein, Elongin-C, Lrr1, ... | | 著者 | Zhou, H, Brown, A. | | 登録日 | 2021-10-09 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates.
Nucleic Acids Res., 49, 2021
|
|
6ZV1
 | |
6ZV2
 | | TFIIS N-terminal domain (TND) from human PPP1R10 | | 分子名称: | Serine/threonine-protein phosphatase 1 regulatory subunit 10 | | 著者 | Veverka, V. | | 登録日 | 2020-07-23 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A ubiquitous disordered protein interaction module orchestrates transcription elongation.
Science, 374, 2021
|
|
5MKE
 | | cryoEM Structure of Polycystin-2 in complex with cations and lipids | | 分子名称: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wilkes, M, Madej, M.G, Ziegler, C. | | 登録日 | 2016-12-04 | | 公開日 | 2017-01-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.
Nat. Struct. Mol. Biol., 24, 2017
|
|
6ZV0
 | |
