5EGS
Human PRMT6 with bound fragment-type inhibitor
Summary for 5EGS
Entry DOI | 10.2210/pdb5egs/pdb |
Related | 4QPP |
Descriptor | Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, 2-[4-(phenylmethyl)piperidin-1-yl]ethanamine, ... (4 entities in total) |
Functional Keywords | fragment, inhibitor, prmt, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q96LA8 |
Total number of polymer chains | 4 |
Total formula weight | 171145.91 |
Authors | Steuber, H.,Egner, U.,Kania, J.,Wu, H.,Brown, P.J. (deposition date: 2015-10-27, release date: 2016-02-03, Last modification date: 2024-01-10) |
Primary citation | Ferreira de Freitas, R.,Eram, M.S.,Szewczyk, M.M.,Steuber, H.,Smil, D.,Wu, H.,Li, F.,Senisterra, G.,Dong, A.,Brown, P.J.,Hitchcock, M.,Moosmayer, D.,Stegmann, C.M.,Egner, U.,Arrowsmith, C.,Barsyte-Lovejoy, D.,Vedadi, M.,Schapira, M. Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. J.Med.Chem., 59:1176-1183, 2016 Cited by PubMed: 26824386DOI: 10.1021/acs.jmedchem.5b01772 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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