5EGS

Human PRMT6 with bound fragment-type inhibitor

Summary for 5EGS

Entry DOI	10.2210/pdb5egs/pdb
Related	4QPP
Descriptor	Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, 2-[4-(phenylmethyl)piperidin-1-yl]ethanamine, ... (4 entities in total)
Functional Keywords	fragment, inhibitor, prmt, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q96LA8
Total number of polymer chains	4
Total formula weight	171145.91
Authors	Steuber, H.,Egner, U.,Kania, J.,Wu, H.,Brown, P.J. (deposition date: 2015-10-27, release date: 2016-02-03, Last modification date: 2024-01-10)
Primary citation	Ferreira de Freitas, R.,Eram, M.S.,Szewczyk, M.M.,Steuber, H.,Smil, D.,Wu, H.,Li, F.,Senisterra, G.,Dong, A.,Brown, P.J.,Hitchcock, M.,Moosmayer, D.,Stegmann, C.M.,Egner, U.,Arrowsmith, C.,Barsyte-Lovejoy, D.,Vedadi, M.,Schapira, M. Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. J.Med.Chem., 59:1176-1183, 2016 Cited by PubMed: 26824386 DOI: 10.1021/acs.jmedchem.5b01772 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation