9AZP
 
 | | INF2 at the Barbed End of F-Actin with Incoming Profilin-Actin | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Palmer, N.J, Barrie, K.R, Dominguez, R. | | 登録日 | 2024-03-11 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.79 Å) | | 主引用文献 | Mechanisms of actin filament severing and elongation by formins.
Nature, 632, 2024
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9B03
 | | INF2 in the Middle of F-Actin (Up state) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Palmer, N.J, Barrie, K.R, Dominguez, R. | | 登録日 | 2024-03-11 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Mechanisms of actin filament severing and elongation by formins.
Nature, 632, 2024
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8XOR
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8D9I
 | | gRAMP non-matching PFS-with Mg | | 分子名称: | RAMP superfamily protein, RNA (35-MER), RNA (5'-R(P*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*A)-3'), ... | | 著者 | Hu, C, Nam, K.H, Schuler, G, Ke, A. | | 登録日 | 2022-06-09 | | 公開日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | | 主引用文献 | Craspase is a CRISPR RNA-guided, RNA-activated protease.
Science, 377, 2022
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4MZL
 | | Crystal Structure of MTIP from Plasmodium falciparum in complex with HBS myoA, a hydrogen bond surrogate myoA helix mimetic | | 分子名称: | Myosin A tail domain interacting protein, hydrogen bond surrogate (HBS) myoA helix mimetic | | 著者 | Douse, C.H, Garnett, J.A, Maas, S.J, Cota, E, Tate, E.W. | | 登録日 | 2013-09-30 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-06-07 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction.
Acs Chem.Biol., 8, 2014
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5CBR
 | | Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution | | 分子名称: | 3,4-dichloro-5-(5-hydroxypyridin-3-yl)-L-phenylalanine, ACETATE ION, GLYCEROL, ... | | 著者 | Frydenvang, K, Kastrup, J.S. | | 登録日 | 2015-07-01 | | 公開日 | 2015-12-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | | 主引用文献 | Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.
J.Med.Chem., 59, 2016
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5CBS
 | | Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution | | 分子名称: | (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Frydenvang, K, Kastrup, J.S. | | 登録日 | 2015-07-01 | | 公開日 | 2015-12-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | | 主引用文献 | Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.
J.Med.Chem., 59, 2016
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4NTT
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6R1B
 | | Crystal structure of UgpB from Mycobacterium tuberculosis in complex with glycerophosphocholine | | 分子名称: | 2-(((R)-2,3-DIHYDROXYPROPYL)PHOSPHORYLOXY)-N,N,N-TRIMETHYLETHANAMINIUM, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Fenn, J, Nepravishta, R, Guy, C.S, Harrison, J, Angulo, J, Cameron, A.D, Fullam, E. | | 登録日 | 2019-03-14 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.27000213 Å) | | 主引用文献 | Structural Basis of Glycerophosphodiester Recognition by theMycobacterium tuberculosisSubstrate-Binding Protein UgpB.
Acs Chem.Biol., 14, 2019
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7VUM
 | | Crystal structure of SSB complexed with que | | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, Single-stranded DNA-binding protein | | 著者 | Lin, E.S, Huang, Y.H, Huang, C.Y. | | 登録日 | 2021-11-03 | | 公開日 | 2022-03-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.319 Å) | | 主引用文献 | A Complexed Crystal Structure of a Single-Stranded DNA-Binding Protein with Quercetin and the Structural Basis of Flavonol Inhibition Specificity.
Int J Mol Sci, 23, 2022
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5CSM
 | | YEAST CHORISMATE MUTASE, T226S MUTANT, COMPLEX WITH TRP | | 分子名称: | CHORISMATE MUTASE, TRYPTOPHAN | | 著者 | Straeter, N, Schnappauf, G, Braus, G, Lipscomb, W.N. | | 登録日 | 1997-07-14 | | 公開日 | 1998-01-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mechanisms of catalysis and allosteric regulation of yeast chorismate mutase from crystal structures.
Structure, 5, 1997
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8SCB
 | | Terminating ribosome with SRI-41315 | | 分子名称: | (2S,4aS)-2-cyclobutyl-10-methyl-3-phenyl-2,10-dihydropyrimido[4,5-b]quinoline-4,5(3H,4aH)-dione, 18S_rRNA, 28S_rRNA, ... | | 著者 | Yip, M.C.J, Coelho, J.P.L, Oltion, K, Tauton, J, Shao, S. | | 登録日 | 2023-04-05 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center.
Nat.Chem.Biol., 20, 2024
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6SS2
 | | Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021158 | | 分子名称: | Arginase-2, mitochondrial, Fab C0021158 heavy chain (IgG1), ... | | 著者 | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | | 登録日 | 2019-09-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mabs, 12
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5DFR
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8EYT
 | | 30S_delta_ksgA+KsgA complex | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Sun, J, Kinman, L.F, Jahagirdar, D, Ortega, J, Davis, J.H. | | 登録日 | 2022-10-28 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion.
Nat.Struct.Mol.Biol., 30, 2023
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6SS4
 | | Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021181 | | 分子名称: | Arginase-2, mitochondrial, Fab C0021181 heavy chain (IgG1), ... | | 著者 | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | | 登録日 | 2019-09-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mabs, 12
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5HIR
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4KAY
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4V6X
 | | Structure of the human 80S ribosome | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R. | | 登録日 | 2013-02-27 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | Structures of the human and Drosophila 80S ribosome.
Nature, 497, 2013
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4M10
 | | Crystal Structure of Murine Cyclooxygenase-2 Complex with Isoxicam | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, ... | | 著者 | Xu, S, Hermanson, D.J, Banerjee, S, Ghebreelasie, K, Marnett, L.J. | | 登録日 | 2013-08-02 | | 公開日 | 2014-01-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.
J.Biol.Chem., 289, 2014
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4W94
 | | Crystal structure of cross-linked tetragonal hen egg white lysozyme soaked with 5mM [Ru(CO)3Cl2]2 | | 分子名称: | CHLORIDE ION, DIMETHYLFORMAMIDE, Lysozyme C, ... | | 著者 | Tabe, H, Fujita, K, Abe, S, Tsujimoto, M, Kuchimaru, T, Kizaka-Kondo, S, Takano, M, Kitagawa, S, Ueno, T. | | 登録日 | 2014-08-27 | | 公開日 | 2014-12-31 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Preparation of a Cross-Linked Porous Protein Crystal Containing Ru Carbonyl Complexes as a CO-Releasing Extracellular Scaffold
Inorg.Chem., 54, 2015
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6MYK
 | | Pleurotus ostreatus OstreolysinA mutant E69A with Bis-Tris | | 分子名称: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Ostreolysin A6, ... | | 著者 | Tomchick, D.R, Radhakrishnan, A, Endapally, S. | | 登録日 | 2018-11-01 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes.
Cell, 176, 2019
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7OI1
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6MYJ
 | | Pleurotus ostreatus OstreolysinA plus sphingomyelin | | 分子名称: | 1,2-ETHANEDIOL, N-[(2S)-1-hydroxypropan-2-yl]butanamide, Ostreolysin A6, ... | | 著者 | Tomchick, D.R, Radhakrishnan, A, Endapally, S. | | 登録日 | 2018-11-01 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes.
Cell, 176, 2019
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4UWN
 | | Lysozyme soaked with a ruthenium based CORM with a methione oxide ligand (complex 6b) | | 分子名称: | CARBON MONOXIDE, CHLORIDE ION, GLYCEROL, ... | | 著者 | Santos, M.F.A, Mukhopadhyay, A, Romao, M.J, Romao, C.C, Santos-Silva, T. | | 登録日 | 2014-08-13 | | 公開日 | 2014-12-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | A Contribution to the Rational Design of Ru(Co)3Cl2L Complexes for in Vivo Delivery of Co.
Dalton Trans, 44, 2015
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