5CBR

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution

Summary for 5CBR

Entry DOI	10.2210/pdb5cbr/pdb
Descriptor	Glutamate receptor 2,Glutamate receptor 2, 3,4-dichloro-5-(5-hydroxypyridin-3-yl)-L-phenylalanine, GLYCEROL, ... (6 entities in total)
Functional Keywords	ampa receptor ligand-binding domain, glua2-s1s2j, antagonist, membrane protein
Biological source	Rattus norvegicus (Norway Rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	1
Total formula weight	30517.60
Authors	Frydenvang, K.,Kastrup, J.S. (deposition date: 2015-07-01, release date: 2015-12-30, Last modification date: 2024-01-10)
Primary citation	Szymanska, E.,Frydenvang, K.,Pickering, D.S.,Krintel, C.,Nielsen, B.,Kooshki, A.,Zachariassen, L.G.,Olsen, L.,Kastrup, J.S.,Johansen, T.N. Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. J.Med.Chem., 59:448-461, 2016 Cited by PubMed: 26653877 DOI: 10.1021/acs.jmedchem.5b01666 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.996 Å)

Structure validation