5CBR
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate receptor 2,Glutamate receptor 2 | polymer | 264 | 29278.7 | 1 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | B (A) | 3,4-dichloro-5-(5-hydroxypyridin-3-yl)-L-phenylalanine | non-polymer | 327.2 | 1 | Chemie (4ZK) | |||
| 3 | C, D, E (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | F, G, H, I, J... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | L (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | M (A) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A: 0 - 114 (UniProt: P19491)
A: 117 - 261 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ala -1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 115 | - | linker |
| Thr 116 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29278.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1238.9 | |
| All* | Total formula weight | 30517.6 |
