5CBR
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue 4ZK A 301 |
| Chain | Residue |
| A | TYR58 |
| A | TYR187 |
| A | LEU188 |
| A | LEU189 |
| A | GLU190 |
| A | MET193 |
| A | TYR217 |
| A | HOH417 |
| A | PRO86 |
| A | LEU87 |
| A | THR88 |
| A | ARG93 |
| A | LEU135 |
| A | SER139 |
| A | THR140 |
| A | THR171 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | ILE89 |
| A | PRO102 |
| A | PRO102 |
| A | LYS215 |
| A | GLY216 |
| A | LEU236 |
| A | ASN239 |
| A | HOH470 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | LYS57 |
| A | TYR58 |
| A | GLY59 |
| A | ALA60 |
| A | ASN69 |
| A | ARG93 |
| A | SO4309 |
| A | HOH417 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | GLU10 |
| A | TYR58 |
| A | LEU135 |
| A | THR170 |
| A | THR171 |
| A | HOH478 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | HIS20 |
| A | LYS141 |
| A | ARG145 |
| A | ARG160 |
| A | HOH403 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | LYS79 |
| A | LYS113 |
| A | SO4308 |
| A | HOH413 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 307 |
| Chain | Residue |
| A | LYS148 |
| A | ARG169 |
| A | GLN241 |
| A | HOH409 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 308 |
| Chain | Residue |
| A | ILE67 |
| A | LYS113 |
| A | LYS182 |
| A | SO4306 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 309 |
| Chain | Residue |
| A | LYS57 |
| A | SER137 |
| A | GLY138 |
| A | GOL303 |
| A | HOH414 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 310 |
| Chain | Residue |
| A | ILE149 |
| A | ALA150 |
| A | LYS246 |
| A | HOH490 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 311 |
| Chain | Residue |
| A | LYS114 |
| A | GLU198 |
| A | MET206 |
| A | HOH449 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
