5CBR

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue 4ZK A 301

Chain	Residue
A	TYR58
A	TYR187
A	LEU188
A	LEU189
A	GLU190
A	MET193
A	TYR217
A	HOH417
A	PRO86
A	LEU87
A	THR88
A	ARG93
A	LEU135
A	SER139
A	THR140
A	THR171

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 302

Chain	Residue
A	ILE89
A	PRO102
A	PRO102
A	LYS215
A	GLY216
A	LEU236
A	ASN239
A	HOH470

---

site_id	AC3
Number of Residues	8
Details	binding site for residue GOL A 303

Chain	Residue
A	LYS57
A	TYR58
A	GLY59
A	ALA60
A	ASN69
A	ARG93
A	SO4309
A	HOH417

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 304

Chain	Residue
A	GLU10
A	TYR58
A	LEU135
A	THR170
A	THR171
A	HOH478

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 305

Chain	Residue
A	HIS20
A	LYS141
A	ARG145
A	ARG160
A	HOH403

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 306

Chain	Residue
A	LYS79
A	LYS113
A	SO4308
A	HOH413

---

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 A 307

Chain	Residue
A	LYS148
A	ARG169
A	GLN241
A	HOH409

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 A 308

Chain	Residue
A	ILE67
A	LYS113
A	LYS182
A	SO4306

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 A 309

Chain	Residue
A	LYS57
A	SER137
A	GLY138
A	GOL303
A	HOH414

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 A 310

Chain	Residue
A	ILE149
A	ALA150
A	LYS246
A	HOH490

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ACT A 311

Chain	Residue
A	LYS114
A	GLU198
A	MET206
A	HOH449

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO86
A	THR88
A	ARG93
A	SER139
A	THR140
A	GLU190

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG61
A	ARG145
A	LYS237

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE118

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER147

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER181

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN0

---