6SS4

Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021181

This is a non-PDB format compatible entry.

Summary for 6SS4

• Entry DOI: 10.2210/pdb6ss4/pdb
• Related: 6SRV 6SRX 6SS0 6SS2 6SS5 6SS6 6TUL
• Descriptor: Arginase-2, mitochondrial, Fab C0021181 heavy chain (IgG1), Fab C0021181 light chain (IgG1), ... (5 entities in total)
• Functional Keywords: arginase-2 inhibitor, igg, antigen-binding fragment, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 85234.02

Authors

Burschowsky, D.,Addyman, A.,Fiedler, S.,Groves, M.,Haynes, S.,Seewooruthun, C.,Carr, M. (deposition date: 2019-09-06, release date: 2020-06-10, Last modification date: 2024-01-24)

• Primary citation: Austin, M.,Burschowsky, D.,Chan, D.T.Y.,Jenkinson, L.,Haynes, S.,Diamandakis, A.,Seewooruthun, C.,Addyman, A.,Fiedler, S.,Ryman, S.,Whitehouse, J.,Slater, L.H.,Hadjinicolaou, A.V.,Gileadi, U.,Gowans, E.,Shibata, Y.,Barnard, M.,Kaserer, T.,Sharma, P.,Luheshi, N.M.,Wilkinson, R.W.,Vaughan, T.J.,Holt, S.V.,Cerundolo, V.,Carr, M.D.,Groves, M.A.T.; Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.; Mabs, 12:1801230-1801230, ; PubMed: 32880207; DOI: 10.1080/19420862.2020.1801230

Experimental method

X-RAY DIFFRACTION (2.9 Å)