4M10

Crystal Structure of Murine Cyclooxygenase-2 Complex with Isoxicam

Summary for 4M10

Related4M11
DescriptorProstaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywordsnsaid, cox, dioxygenase, peroxidase, glycosylation, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceMus musculus (mouse)
Cellular locationMicrosome membrane; Peripheral membrane protein Q05769
Total number of polymer chains4
Total molecular weight277846.94
Authors
Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreelasie, K.,Marnett, L.J. (deposition date: 2013-08-02, release date: 2014-01-22, Last modification date: 2014-05-14)
Primary citation
Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreselasie, K.,Clayton, G.M.,Garavito, R.M.,Marnett, L.J.
Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.
J.Biol.Chem., 289:6799-6808, 2014
PubMed: 24425867 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M113.517987
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.01 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21930.1%3.5%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution