Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam

Summary for 4M11

Related4M10 3NT1 4FM5 4LLZ
DescriptorProstaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywordsnsaid, cox, dioxygenase, peroxidase, glycosylation, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceMus musculus (mouse)
Cellular locationMicrosome membrane; Peripheral membrane protein Q05769
Total number of polymer chains4
Total molecular weight261985.31
Xu, S.,Banerjee, S.,Hermanson, D.J.,Marnett, L.J. (deposition date: 2013-08-02, release date: 2014-01-22, Last modification date: 2014-05-14)
Primary citation
Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreselasie, K.,Clayton, G.M.,Garavito, R.M.,Marnett, L.J.
Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.
J.Biol.Chem., 289:6799-6808, 2014
PubMed: 24425867 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M113.517987
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.229705.4%2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report