PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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8PTO	Structure of Rho pentamer in complex with Rof and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein rof, Transcription termination factor Rho 著者 Said, N, Hilal, T, Wahl, M.C. 登録日 2023-07-14 公開日 2024-04-17 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Sm-like protein Rof inhibits transcription termination factor rho by binding site obstruction and conformational insulation. Nat Commun, 15, 2024
6TPA	CDK8/CyclinC in complex with drug ETP-50775 分子名称: (2~{R})-butane-1,2-diol, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)urea, Cyclin-C, ... 著者 Munoz, I.G, Pastor, J, Martinez, S. 登録日 2019-12-12 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors. Eur.J.Med.Chem., 201, 2020
5V8W	Crystal structure of human Integrator IntS9-IntS11 CTD complex 分子名称: Integrator complex subunit 11, Integrator complex subunit 9 著者 Wu, Y, Tong, L. 登録日 2017-03-22 公開日 2017-04-12 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4IUM	Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin 分子名称: GLYCEROL, Ubiquitin, ZINC ION, ... 著者 Bailey-Elkin, B.A, James, T.W, Mark, B.L. 登録日 2013-01-21 公開日 2013-02-13 最終更新日 2013-03-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. Proc.Natl.Acad.Sci.USA, 110, 2013
4ZTU	Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*AP*GP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ... 著者 Szymanski, M.R, Kuznestov, V.B, Shumate, C.K, Meng, Q, Lee, Y.-S, Patel, G, Patel, S.S, Yin, Y.W. 登録日 2015-05-15 公開日 2015-09-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.299 Å) 主引用文献 Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase EMBO J., 34, 2015
5WOZ	NMR solution structure of Rtt103 (RTT) protein using two 4D-spectra 分子名称: Regulator of Ty1 transposition protein 103 著者 Evangelidis, T, Nerli, S, Sgourakis, N.G, Tripsianes, K. 登録日 2017-08-03 公開日 2018-02-07 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Automated NMR resonance assignments and structure determination using a minimal set of 4D spectra. Nat Commun, 9, 2018
3BRD	CSL (Lag-1) bound to DNA with Lin-12 RAM peptide, P212121 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*DAP*DAP*DTP*DCP*DTP*DTP*DTP*DCP*DCP*DCP*DAP*DCP*DAP*DGP*DT)-3'), DNA (5'-D(*DTP*DTP*DAP*DCP*DTP*DGP*DTP*DGP*DGP*DGP*DAP*DAP*DAP*DGP*DA)-3'), ... 著者 Wilson, J.J, Kovall, R.A. 登録日 2007-12-21 公開日 2008-04-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex. J.Biol.Chem., 283, 2008
3BRF	CSL (Lag-1) bound to DNA with Lin-12 RAM peptide, C2221 分子名称: DNA (5'-D(*DAP*DAP*DTP*DCP*DTP*DTP*DTP*DCP*DCP*DCP*DAP*DCP*DAP*DGP*DT)-3'), DNA (5'-D(*DTP*DTP*DAP*DCP*DTP*DGP*DTP*DGP*DGP*DGP*DAP*DAP*DAP*DGP*DA)-3'), Lin-12 and glp-1 phenotype protein 1, ... 著者 Wilson, J.J, Kovall, R.A. 登録日 2007-12-21 公開日 2008-04-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex. J.Biol.Chem., 283, 2008
5FFM	Yellow fever virus helicase 分子名称: Serine protease NS3 著者 Smith, J.L. 登録日 2015-12-18 公開日 2015-12-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing. J. Virol., 79, 2005
3K5O	Crystal structure of E.coli Pol II 分子名称: DNA polymerase II 著者 Yang, W, Wang, F. 登録日 2009-10-07 公開日 2010-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural insight into translesion synthesis by DNA Pol II. Cell(Cambridge,Mass.), 139, 2009
6ZWP	p38a bound with SR348 分子名称: 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[(4-fluorophenyl)amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 著者 Schroeder, M, Roehm, S, Knapp, S, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Structural Genomics Consortium (SGC) 登録日 2020-07-28 公開日 2020-08-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
3K5N	Crystal structure of E.coli Pol II-abasic DNA binary complex 分子名称: DNA (5'-D(*GP*TP*CP*CP*TP*GP*(3DR)*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*G)-3'), DNA polymerase II 著者 Yang, W, Wang, F. 登録日 2009-10-07 公開日 2010-02-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structural insight into translesion synthesis by DNA Pol II. Cell(Cambridge,Mass.), 139, 2009
4ZTZ	Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*AP*GP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ... 著者 Szymanski, M.R, Yin, Y.W. 登録日 2015-05-15 公開日 2015-09-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.442 Å) 主引用文献 Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase EMBO J., 34, 2015
8CBQ	structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome 分子名称: Histone H2A, Histone H2B 1.1, Histone H3, ... 著者 Koutna, E, Kouba, T, Novacek, J, Veverka, V. 登録日 2023-01-25 公開日 2023-09-06 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
8CBN	structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome 分子名称: Histone H2A, Histone H2B 1.1, Histone H3, ... 著者 Koutna, E, Kouba, T, Novacek, J, Veverka, V. 登録日 2023-01-25 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
2NPI	Clp1-ATP-Pcf11 complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein CLP1, ... 著者 Noble, C.G, Beuth, B, Taylor, I.A. 登録日 2006-10-27 公開日 2006-12-19 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor Nucleic Acids Res., 35, 2007
2HWK	Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain 分子名称: FORMIC ACID, helicase nsP2 著者 Russo, A.T, White, M.A, Watowich, S.J. 登録日 2006-08-01 公開日 2006-09-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 The Crystal Structure of the Venezuelan Equine Encephalitis Alphavirus nsP2 Protease. Structure, 14, 2006
6WBV	Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc 分子名称: (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE, COBALT (II) ION, Fab45D8 Heavy Chain, ... 著者 Billesboelle, C.B, Azumaya, C.M, Gonen, S, Powers, A, Kretsch, R.C, Schneider, S, Arvedson, T, Dror, R.O, Cheng, Y, Manglik, A. 登録日 2020-03-27 公開日 2020-09-09 最終更新日 2020-11-11 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature, 586, 2020
7X1N	Crystal structure of MEF2D-MRE complex 分子名称: DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein 著者 Zhang, H, Zhang, M, Wang, Q.Q, Chen, Z, Chen, S.J, Meng, G. 登録日 2022-02-24 公開日 2022-05-25 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.315 Å) 主引用文献 Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion. Blood, 140, 2022
6WK2	SETD3 mutant (N255V) in Complex with an Actin Peptide with His73 Replaced with Methionine 分子名称: 1,2-ETHANEDIOL, Actin, cytoplasmic 2, ... 著者 Dai, S, Horton, J.R, Cheng, X. 登録日 2020-04-15 公開日 2020-06-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J.Biol.Chem., 295, 2020
6WK1	SETD3 in Complex with an Actin Peptide with His73 Replaced with Methionine 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Actin, ... 著者 Dai, S, Horton, J.R, Cheng, X. 登録日 2020-04-15 公開日 2020-06-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J.Biol.Chem., 295, 2020
7WVK	Crystal structure of human WDR5 in complex with compound 19 分子名称: 1,2-ETHANEDIOL, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ... 著者 Han, Q.L, Zhang, X.L, Wang, L, Ren, P.X, Cao, Y, Li, K, Bai, F. 登録日 2022-02-10 公開日 2022-10-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol.Sin., 44, 2023
7LUV	Cryo-EM structure of the yeast THO-Sub2 complex 分子名称: ATP-dependent RNA helicase SUB2, THO complex subunit 2, THO complex subunit HPR1, ... 著者 Xie, Y, Ren, Y. 登録日 2021-02-23 公開日 2021-04-14 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2. Elife, 10, 2021
8DW6	T4 bacteriophage primosome with single-strand DNA, State 3 分子名称: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA (70-MER), DNA primase, ... 著者 Feng, X, Li, H. 登録日 2022-07-31 公開日 2023-06-14 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of the T4 bacteriophage primosome assembly and primer synthesis. Nat Commun, 14, 2023
8SVF	BAP1/ASXL1 bound to the H2AK119Ub Nucleosome 分子名称: DNA/RNA (187-MER), DNA/RNA (327-MER), Histone H2A type 1, ... 著者 Thomas, J.F, Valencia-Sanchez, M.I, Armache, K.-J. 登録日 2023-05-16 公開日 2023-08-30 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1. Sci Adv, 9, 2023

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