2HWK

Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain

Summary for 2HWK

• Entry DOI: 10.2210/pdb2hwk/pdb
• Descriptor: helicase nsP2, FORMIC ACID (3 entities in total)
• Functional Keywords: rossmann fold, alpha/beta/alpha, multi-domain, hydrolase
• Biological source: Venezuelan equine encephalitis virus (strain TC-83)
• Cellular location: Non-structural polyprotein: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . mRNA-capping enzyme nsP1: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Protease nsP2: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase nsP4: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side : P27282
• Total number of polymer chains: 1
• Total formula weight: 36377.49

Authors

Russo, A.T.,White, M.A.,Watowich, S.J. (deposition date: 2006-08-01, release date: 2006-09-26, Last modification date: 2024-02-14)

• Primary citation: Russo, A.T.,White, M.A.,Watowich, S.J.; The Crystal Structure of the Venezuelan Equine Encephalitis Alphavirus nsP2 Protease.; Structure, 14:1449-1458, 2006; PubMed: 16962975; DOI: 10.1016/j.str.2006.07.010

Experimental method

X-RAY DIFFRACTION (2.45 Å)