8RBZ
 
 | | Structure of Integrator-PP2A-SOSS-CTD post-termination complex | | 分子名称: | DNA-directed RNA polymerase subunit, DSS1, Integrator complex subunit 1, ... | | 著者 | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | | 登録日 | 2023-12-05 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
|
|
7LBM
 | | Structure of the human Mediator-bound transcription pre-initiation complex | | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | 著者 | Abdella, R, Talyzina, A, He, Y. | | 登録日 | 2021-01-08 | | 公開日 | 2021-03-24 | | 最終更新日 | 2021-04-14 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structure of the human Mediator-bound transcription preinitiation complex.
Science, 372, 2021
|
|
3HK0
 | |
5K5F
 | | NMR structure of the HLTF HIRAN domain | | 分子名称: | Helicase-like transcription factor | | 著者 | Bezsonova, I, Neculai, D, Korzhnev, D, Weigelt, J, Bountra, C, Edwards, A, Arrowsmith, C, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2016-05-23 | | 公開日 | 2016-06-08 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of the HLTF HIRAN domain
To Be Published
|
|
8Q0N
 | | HACE1 in complex with RAC1 Q61L | | 分子名称: | E3 ubiquitin-protein ligase HACE1, GUANOSINE-5'-TRIPHOSPHATE, Ras-related C3 botulinum toxin substrate 1, ... | | 著者 | Wolter, M, Duering, J, Dienemann, C, Lorenz, S. | | 登録日 | 2023-07-28 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1.
Nat.Struct.Mol.Biol., 31, 2024
|
|
7SJ4
 | | Human Trio residues 1284-1959 in complex with Rac1 | | 分子名称: | Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein | | 著者 | Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G. | | 登録日 | 2021-10-15 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
J.Biol.Chem., 298, 2022
|
|
6OSM
 | |
6OSJ
 | |
6OSL
 | |
6PES
 | | Cryo-EM structure of alpha-synuclein H50Q Wide Fibril | | 分子名称: | Alpha-synuclein | | 著者 | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | | 登録日 | 2019-06-20 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
|
|
6PCV
 | | Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 | | 著者 | Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G. | | 登録日 | 2019-06-18 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
|
|
6PEO
 | | Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril | | 分子名称: | Alpha-synuclein | | 著者 | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | | 登録日 | 2019-06-20 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
|
|
4P3W
 | |
1W9E
 | | Crystal structure of the PDZ tandem of human syntenin in complex with TNEFYF peptide | | 分子名称: | BENZOIC ACID, SYNTENIN 1, TNEFYF PEPTIDE | | 著者 | Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | | 登録日 | 2004-10-09 | | 公開日 | 2006-03-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
|
|
1W9O
 | | Crystal structure of the PDZ tandem of human syntenin in complex with TNEYYV peptide | | 分子名称: | BENZOIC ACID, SYNTENIN 1, TNEYYV PEPTIDE | | 著者 | Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | | 登録日 | 2004-10-15 | | 公開日 | 2006-03-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
|
|
4YON
 | | P-Rex1:Rac1 complex | | 分子名称: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Lucato, C.M, Whisstock, J.C, Ellisdon, A.M. | | 登録日 | 2015-03-11 | | 公開日 | 2015-07-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J.Biol.Chem., 290, 2015
|
|
6X1G
 | |
2XN4
 | | Crystal structure of the kelch domain of human KLHL2 (Mayven) | | 分子名称: | 1,2-ETHANEDIOL, KELCH-LIKE PROTEIN 2, SODIUM ION, ... | | 著者 | Canning, P, Hozjan, V, Cooper, C.D.O, Ayinampudi, V, Vollmar, M, Pike, A.C.W, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. | | 登録日 | 2010-07-30 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
|
|
6KTO
 | |
3RGH
 | |
8J07
 | |
3GV4
 | | Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG | | 分子名称: | CALCIUM ION, Histone deacetylase 6, ZINC ION, ... | | 著者 | Dong, A, Ravichandran, M, Loppnau, P, Li, Y, MacKenzie, F, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Dhe-Paganon, S, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | | 登録日 | 2009-03-30 | | 公開日 | 2009-04-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG
To be Published
|
|
7LS1
 | | 80S ribosome from mouse bound to eEF2 (Class II) | | 分子名称: | 28S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | | 登録日 | 2021-02-17 | | 公開日 | 2021-11-03 | | 最終更新日 | 2021-12-08 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Nat Commun, 12, 2021
|
|
7LS2
 | | 80S ribosome from mouse bound to eEF2 (Class I) | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | 著者 | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | | 登録日 | 2021-02-17 | | 公開日 | 2021-11-03 | | 最終更新日 | 2021-12-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Nat Commun, 12, 2021
|
|
4UAL
 | | MRCK beta in complex with BDP00005290 | | 分子名称: | 1,2-ETHANEDIOL, 4-chloro-1-(piperidin-4-yl)-N-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-1H-pyrazole-3-carboxamide, CHLORIDE ION, ... | | 著者 | Schuettelkopf, A.W. | | 登録日 | 2014-08-10 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
Cell Commun. Signal, 12, 2014
|
|
