PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

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7QO6	26S proteasome Rpt1-RK -Ubp6-UbVS complex in the s2 state 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ... 著者 Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, T.C, Joshi, T, Rudack, T, Sakata, E, Finley, D. 登録日 2021-12-23 公開日 2022-03-16 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (6.3 Å) 主引用文献 Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nat Commun, 13, 2022
5FA5	Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Histone H4, Methylosome protein 50, ... 著者 Sprague, E.R, McNamara, J.T. 登録日 2015-12-10 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science, 351, 2016
5IY4	Crystal structure of human PCNA in complex with the PIP box of DVC1 分子名称: DVC1 PIP box, Proliferating cell nuclear antigen 著者 Jiang, T, Xu, M, Wang, Y. 登録日 2016-03-24 公開日 2016-06-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.945 Å) 主引用文献 Crystal structure of human PCNA in complex with the PIP box of DVC1 Biochem.Biophys.Res.Commun., 474, 2016
8PTP	Structure of Rho pentamer in complex with Rof 分子名称: Protein rof, Transcription termination factor Rho 著者 Said, N, Hilal, T, Wahl, M.C. 登録日 2023-07-14 公開日 2024-04-17 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Sm-like protein Rof inhibits transcription termination factor rho by binding site obstruction and conformational insulation. Nat Commun, 15, 2024
8PTN	Structure of the transcription termination factor Rho in complex with Rof 分子名称: Protein rof, Transcription termination factor Rho 著者 Said, N, Hilal, T, Wahl, M.C. 登録日 2023-07-14 公開日 2024-04-17 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Sm-like protein Rof inhibits transcription termination factor rho by binding site obstruction and conformational insulation. Nat Commun, 15, 2024
8PTM	Structure of the transcription termination factor Rho in complex with Rof and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein rof, ... 著者 Said, N, Hilal, T, Wahl, M.C. 登録日 2023-07-14 公開日 2024-04-17 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Sm-like protein Rof inhibits transcription termination factor rho by binding site obstruction and conformational insulation. Nat Commun, 15, 2024
3BRG	CSL (RBP-Jk) bound to DNA 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*DAP*DAP*DTP*DCP*DTP*DTP*DTP*DCP*DCP*DCP*DAP*DCP*DAP*DGP*DT)-3'), DNA (5'-D(*DTP*DTP*DAP*DCP*DTP*DGP*DTP*DGP*DGP*DGP*DAP*DAP*DAP*DGP*DA)-3'), ... 著者 Friedmann, D.R, Kovall, R.A. 登録日 2007-12-21 公開日 2008-04-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex. J.Biol.Chem., 283, 2008
4JY0	Crystal structure of hcv ns5b polymerase in complex with compound 3 分子名称: (4S,5R)-1-(4-tert-butylbenzoyl)-2-(2-methylpropyl)-4-pyrazin-2-yl-5-(1,3-thiazol-2-yl)-L-proline, Genome polyprotein 著者 Coulombe, R. 登録日 2013-03-28 公開日 2014-04-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Distinguishing drug binding pockets on proteins by complementary biophysical and biological methods. To be Published
3GQE	Crystal structure of macro domain of Venezuelan Equine Encephalitis virus 分子名称: BICINE, Non-structural protein 3 著者 Jamal, S, Malet, H, Coutard, B, Canard, B. 登録日 2009-03-24 公開日 2009-07-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket J.Virol., 83, 2009
7N5C	6218 TCR in complex with H2Db PA with an engineered TCR-pMHC disulfide bond 分子名称: Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 with T-cell receptor, sp3.4 alpha chain, ... 著者 Szeto, C, Gras, S. 登録日 2021-06-05 公開日 2022-07-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
5F79	Influenza PB2 bound to an azaindole inhibitor 分子名称: N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide, Polymerase basic protein 2 著者 Jacobs, M.D. 登録日 2015-12-07 公開日 2016-12-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza. ACS Med Chem Lett, 8, 2017
8OR0	CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, Cyclin-dependent kinase 2, ... 著者 Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. 登録日 2023-04-12 公開日 2023-06-28 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. Mol.Cell, 83, 2023
3ZNG	Ankyrin repeat and SOCS-box protein 9 (ASB9) in complex with ElonginB and ElonginC 分子名称: 1,2-ETHANEDIOL, ANKYRIN REPEAT AND SOCS BOX PROTEIN 9, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... 著者 Thomas, J, Van Molle, I, Ciulli, A. 登録日 2013-02-14 公開日 2013-12-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Multimeric Complexes Among Ankyrin-Repeat and Socs-Box Protein 9 (Asb9), Elonginbc, and Cullin 5: Insights Into the Structure and Assembly of Ecs-Type Cullin-Ring E3 Ubiquitin Ligases. Biochemistry, 52, 2013
3DU5	Structure of the catalytic subunit of telomerase, TERT 分子名称: Telomerase reverse transcriptase 著者 Skordalakes, E. 登録日 2008-07-16 公開日 2008-08-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature, 455, 2008
3DU6	Structure of the catalytic subunit of telomerase, TERT 分子名称: Telomerase reverse transcriptase 著者 Skordalakes, E. 登録日 2008-07-16 公開日 2008-08-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature, 455, 2008
7M7R	Human DNA Pol eta S113A with rA-ended primer and dAMPNPP 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... 著者 Gregory, M.T, Gao, Y, Yang, W. 登録日 2021-03-28 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
7M8B	Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 140 s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... 著者 Gregory, M.T, Gao, Y, Yang, W. 登録日 2021-03-29 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
7M8D	Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 300 s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Gregory, M.T, Gao, Y, Yang, W. 登録日 2021-03-29 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
7M89	Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 0 s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Gregory, M.T, Gao, Y, Yang, W. 登録日 2021-03-29 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
7M7M	Human DNA Pol eta with rA-ended primer and dAMPNPP 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... 著者 Gregory, M.T, Gao, Y, Yang, W. 登録日 2021-03-28 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
7M8A	Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 40 s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... 著者 Gregory, M.T, Gao, Y, Yang, W. 登録日 2021-03-29 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
7M8C	Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 230 s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... 著者 Gregory, M.T, Gao, Y, Yang, W. 登録日 2021-03-29 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
5WJI	Crystal structure of the F61S mutant of HsNUDT16 分子名称: ACETIC ACID, CHLORIDE ION, SULFATE ION, ... 著者 Thirawatananond, P, Gabelli, S.B. 登録日 2017-07-23 公開日 2018-10-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. Sci Rep, 9, 2019
3GPO	Crystal structure of macro domain of Chikungunya virus in complex with ADP-ribose 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, Non-structural protein 3 著者 Malet, H, Jamal, S, Coutard, B, Canard, B. 登録日 2009-03-23 公開日 2009-07-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket J.Virol., 83, 2009
2BAL	p38alpha MAP kinase bound to pyrazoloamine 分子名称: Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE 著者 Gerhardt, S, Pauptit, R.A, Read, J, Tucker, J, Norman, R.A, Breed, J. 登録日 2005-10-14 公開日 2005-12-06 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase. Biochemistry, 44, 2005

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