5F79

Influenza PB2 bound to an azaindole inhibitor

Summary for 5F79

• Entry DOI: 10.2210/pdb5f79/pdb
• Descriptor: Polymerase basic protein 2, N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide (3 entities in total)
• Functional Keywords: small molecule inhibitor, polymerase, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Influenza A virus
• Cellular location: Virion: Q30NP1
• Total number of polymer chains: 1
• Total formula weight: 19645.83

Authors

Jacobs, M.D. (deposition date: 2015-12-07, release date: 2016-12-07, Last modification date: 2023-09-27)

• Primary citation: Bandarage, U.K.,Clark, M.P.,Perola, E.,Gao, H.,Jacobs, M.D.,Tsai, A.,Gillespie, J.,Kennedy, J.M.,Maltais, F.,Ledeboer, M.W.,Davies, I.,Gu, W.,Byrn, R.A.,Nti Addae, K.,Bennett, H.,Leeman, J.R.,Jones, S.M.,O'Brien, C.,Memmott, C.,Bennani, Y.,Charifson, P.S.; Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.; ACS Med Chem Lett, 8:261-265, 2017; PubMed: 28197323; DOI: 10.1021/acsmedchemlett.6b00487

Experimental method

X-RAY DIFFRACTION (2.4 Å)