3GQE

Crystal structure of macro domain of Venezuelan Equine Encephalitis virus

Summary for 3GQE

Related3GPG 3GPO 3GPQ
DescriptorNon-structural protein 3, BICINE (3 entities in total)
Functional Keywordsmacro domain, x domain, venezuelan equine encephalitis virus, alphavirus, virus, vizier. viral enzymes involved in replication, atp-binding, cell membrane, cell projection, endosome, helicase, hydrolase, lipoprotein, lysosome, membrane, methyltransferase, mrna capping, mrna processing, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, palmitate, phosphoprotein, protease, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, viral protein
Biological sourceVenezuelan equine encephalitis virus
Cellular locationNon-structural polyprotein: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). P123: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). P123': Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). mRNA-capping enzyme nsP1: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Protease nsP2: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 3: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 3': Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). RNA-directed RNA polymerase nsP4: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) P36328
Total number of polymer chains2
Total molecular weight36892.91
Authors
Jamal, S.,Malet, H.,Coutard, B.,Canard, B. (deposition date: 2009-03-24, release date: 2009-07-21, Last modification date: 2011-07-13)
Primary citation
Malet, H.,Coutard, B.,Jamal, S.,Dutartre, H.,Papageorgiou, N.,Neuvonen, M.,Ahola, T.,Forrester, N.,Gould, E.A.,Lafitte, D.,Ferron, F.,Lescar, J.,Gorbalenya, A.E.,de Lamballerie, X.,Canard, B.
The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83:6534-6545, 2009
PubMed: 19386706 (PDB entries with the same primary citation)
DOI: 10.1128/JVI.00189-09
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.270110.3%7.0%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3gqe
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Molmil generated image of 3gqe
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Molmil generated image of 3gqe
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More Biological unit images

Molmil generated image of 3gqe
no rotation
Molmil generated image of 3gqe
rotated about x axis by 90°
Molmil generated image of 3gqe
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3gqe.pdb1.gz [29.06 KB])
Coordinate files for Biological unit (3gqe.pdb2.gz [26.67 KB])