8QKJ
 
 | | PvSub1 Catalytic Domain in Complex with Peptidomimetic Inhibitor (MAM-133) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Peptidomimetic Inhibitor (MAM-133), ... | | 著者 | Batista, F.A, Martinez, M, Bouillon, A, Mechaly, A, Alzari, P.M, Haouz, A, Barale, J.C. | | 登録日 | 2023-09-15 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.767 Å) | | 主引用文献 | Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Eur.J.Med.Chem., 269, 2024
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3ZPV
 | | Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain | | 分子名称: | PROTEIN BCL9 HOMOLOG, PROTEIN PYGOPUS, ZINC ION | | 著者 | Miller, T.C.R, Mieszczanek, J, Sanchez-Barrena, M.J, Rutherford, T.J, Fiedler, M, Bienz, M. | | 登録日 | 2013-03-02 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Evolutionary Adaptation of the Fly Pygo Phd Finger Towards Recognizing Histone H3 Tail Methylated at Arginine 2
Structure, 21, 2013
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7M6K
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7MKK
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8QH0
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8QKG
 | | PvSub1 Catalytic Domain in Complex with Peptidomimetic Inhibitor (MAM-125) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Peptidomimetic Inhibitor (MAM-125), ... | | 著者 | Batista, F.A, Martinez, M, Bouillon, A, Mechaly, A, Alzari, P.M, Haouz, A, Barale, J.C. | | 登録日 | 2023-09-15 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.538 Å) | | 主引用文献 | Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Eur.J.Med.Chem., 269, 2024
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7UAB
 | | Human pro-meprin alpha (zymogen state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | | 登録日 | 2022-03-12 | | 公開日 | 2022-11-02 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
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7UAC
 | | Human pro-meprin alpha (zymogen state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Meprin A subunit alpha, ... | | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | | 登録日 | 2022-03-12 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
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7UOV
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7UAI
 | | Meprin alpha helix in complex with fetuin-B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | | 登録日 | 2022-03-13 | | 公開日 | 2022-11-02 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
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7UAE
 | | Human meprin alpha (active state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | | 登録日 | 2022-03-12 | | 公開日 | 2022-11-02 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
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7UAF
 | | Human meprin alpha inhibitory complex with compound 10d (N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-beta-alaninamide) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | | 登録日 | 2022-03-12 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
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8Q5D
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8AM9
 | | Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the elongating ribosome | | 分子名称: | 16S ribosomal RNA, 2-acetamido-2-deoxy-alpha-D-galactopyranose, 23S ribosomal RNA, ... | | 著者 | Koller, T.O, Morici, M, Wilson, D.N. | | 登録日 | 2022-08-03 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis for translation inhibition by the glycosylated drosocin peptide.
Nat.Chem.Biol., 19, 2023
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8AKN
 | | Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the terminating ribosome | | 分子名称: | 16S ribosomal RNA, 2-acetamido-2-deoxy-alpha-D-galactopyranose, 23S ribosomal RNA, ... | | 著者 | Koller, T.O, Morici, M, Wilson, D.N. | | 登録日 | 2022-07-30 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Structural basis for translation inhibition by the glycosylated drosocin peptide.
Nat.Chem.Biol., 19, 2023
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8ANA
 | | Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the 50S ribosomal subunit | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 23S ribosomal RNA, 50S ribosomal protein L13, ... | | 著者 | Koller, T.O, Morici, M, Wilson, D.N. | | 登録日 | 2022-08-05 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | | 主引用文献 | Structural basis for translation inhibition by the glycosylated drosocin peptide.
Nat.Chem.Biol., 19, 2023
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8PHI
 | | Crystal structure of prefusion-stabilized RSV F Variant DS-Cav1 in complex with Lonafarnib | | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, CALCIUM ION, ... | | 著者 | Rajak, M, Krey, T. | | 登録日 | 2023-06-19 | | 公開日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.289 Å) | | 主引用文献 | Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Nat Commun, 15, 2024
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7TYV
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7ME4
 | | Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITOLEIC ACID, Tyrosine-protein kinase transmembrane receptor Ror2 | | 著者 | Mendrola, J.M, Shi, F, Perry, K, Stayrook, S.E, Lemmon, M.A. | | 登録日 | 2021-04-06 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
Cell Rep, 37, 2021
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7ME5
 | | Structure of the extracellular WNT-binding module in Drl-2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tyrosine-protein kinase transmembrane receptor DRL-2 | | 著者 | Shi, F, Mendrola, J.M, Perry, K, Stayrook, S.E, Lemmon, M.A. | | 登録日 | 2021-04-06 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
Cell Rep, 37, 2021
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8B9L
 | | Cryo-EM structure of MLE | | 分子名称: | Dosage compensation regulator | | 著者 | Jagtap, P.K.A, Hennig, J. | | 登録日 | 2022-10-06 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | | 主引用文献 | Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless.
Mol.Cell, 83, 2023
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7MSJ
 | | The crystal structure of mouse HVEM | | 分子名称: | SULFATE ION, Tumor necrosis factor receptor superfamily member 14 | | 著者 | Liu, W, Ramagopal, U, Garrett-Thompson, S.C, Fedorov, E, Bonanno, J.B, Almo, S.C. | | 登録日 | 2021-05-11 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
J.Exp.Med., 218, 2021
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8B9J
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8B9K
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8B9I
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