7UAB

Human pro-meprin alpha (zymogen state)

Summary for 7UAB

Entry DOI	10.2210/pdb7uab/pdb
EMDB information	26419 26420 26421 26422 26423 26424 26426
Descriptor	Meprin A subunit alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	metalloprotease, complex, helical, extracellular, oncoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	276486.89
Authors	Bayly-Jones, C.,Lupton, C.J.,Fritz, C.,Schlenzig, D.,Whisstock, J.C. (deposition date: 2022-03-12, release date: 2022-11-02)
Primary citation	Bayly-Jones, C.,Lupton, C.J.,Fritz, C.,Venugopal, H.,Ramsbeck, D.,Wermann, M.,Jager, C.,de Marco, A.,Schilling, S.,Schlenzig, D.,Whisstock, J.C. Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor. Nat Commun, 13:6178-6178, 2022 Cited by PubMed: 36261433 DOI: 10.1038/s41467-022-33893-7 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation