7UAB

Human pro-meprin alpha (zymogen state)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, E, H	Meprin A subunit alpha	polymer	587	67285.8	4	UniProt (Q16819) Pfam (PF01400) Pfam (PF00629) Pfam (PF22486) In PDB	Homo sapiens (human)	Endopeptidase-2,N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha,PABA peptide hydrolase,PPH alpha
2	B, F, I, K, L...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	7	In PDB GlyTouCan (G42666HT)
3	C, G, J, N	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	4	In PDB GlyTouCan (G21290RB)
4	H, A, D, E	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)
5	E, H, A, D	CALCIUM ION	non-polymer		40.1	7	Chemie (CA)
6	E, H, A, D	ZINC ION	non-polymer		65.4	4	Chemie (ZN)

Sequence modifications

A, D, E, H: 22 - 600 (UniProt: Q16819)

PDB	External Database	Details
Trp 14	-	expression tag
Ser 15	-	expression tag
His 16	-	expression tag
Pro 17	-	expression tag
Gln 18	-	expression tag
Phe 19	-	expression tag
Glu 20	-	expression tag
Lys 21	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	269143.3
Branched	Number of molecules	11
	Total formula weight	5253.0
Non-Polymers*	Number of molecules	18
	Total formula weight	2090.6
All*	Total formula weight	276486.9

*Water molecules are not included.