7M6K

Crystal structure of the ARM domain from Drosophila SARM1 in complex with VMN

Summary for 7M6K

• Entry DOI: 10.2210/pdb7m6k/pdb
• Descriptor: Isoform B of NAD(+) hydrolase sarm1, 3-({[(4-nitrophenyl)carbamoyl]amino}methyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium, SODIUM ION, ... (4 entities in total)
• Functional Keywords: neurotoxicity, axon degeneration, nadase, arm domain, immune system
• Biological source: Drosophila melanogaster (Fruit fly)
• Total number of polymer chains: 2
• Total formula weight: 69817.52

Authors

Gu, W.,Luo, Z.,Kobe, B. (deposition date: 2021-03-25, release date: 2022-02-02, Last modification date: 2023-10-18)

• Primary citation: Loreto, A.,Angeletti, C.,Gu, W.,Osborne, A.,Nieuwenhuis, B.,Gilley, J.,Merlini, E.,Arthur-Farraj, P.,Amici, A.,Luo, Z.,Hartley-Tassell, L.,Ve, T.,Desrochers, L.M.,Wang, Q.,Kobe, B.,Orsomando, G.,Coleman, M.P.; Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.; Elife, 10:-, 2021; PubMed: 34870595; DOI: 10.7554/eLife.72823

Experimental method

X-RAY DIFFRACTION (1.69 Å)