PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

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5BUH	Influenza PB2 bound to a hydroxymethyl azaindole inhibitor 分子名称: N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide, Polymerase basic protein 2 著者 Jacobs, M.D. 登録日 2015-06-03 公開日 2016-06-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza. ACS Med Chem Lett, 8, 2017
3FQD	Crystal Structure of the S. pombe Rat1-Rai1 Complex 分子名称: 5'-3' exoribonuclease 2, GLYCEROL, MAGNESIUM ION, ... 著者 Xiang, S, Tong, L. 登録日 2009-01-07 公開日 2009-02-03 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature, 458, 2009
5HHJ	Reverse transcriptase domain of group II intron maturase from Roseburia intestinalis in P21 space group 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCINE, PHOSPHATE ION, ... 著者 Zhao, C, Pyle, A.M. 登録日 2016-01-11 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nat.Struct.Mol.Biol., 23, 2016
7VOI	Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex 分子名称: CCR4-NOT transcription complex subunit 1, CCR4-NOT transcription complex subunit 6-like, CCR4-NOT transcription complex subunit 7 著者 Bartlam, M, Zhang, Q. 登録日 2021-10-13 公開日 2022-06-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (4.38 Å) 主引用文献 Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements. Protein Sci., 31, 2022
6B09	Crystal structure of HsNUDT16 in complex with diADPR (soaked) 分子名称: CHLORIDE ION, MAGNESIUM ION, SODIUM ION, ... 著者 Thirawatananond, P, Gabelli, S.B. 登録日 2017-09-14 公開日 2019-01-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. Sci Rep, 9, 2019
5IRF	Reverse transcriptase domain of group II intron maturase from Roseburia intestinalis in P1 space group 分子名称: POTASSIUM ION, Retron-type reverse transcriptase 著者 Zhao, C, Pyle, A.M. 登録日 2016-03-13 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nat.Struct.Mol.Biol., 23, 2016
5IRG	Reverse transcriptase domain of group II intron maturase from Roseburia intestinalis in P212121 space group 分子名称: POTASSIUM ION, Retron-type reverse transcriptase 著者 Zhao, C, Pyle, A.M. 登録日 2016-03-13 公開日 2016-05-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nat.Struct.Mol.Biol., 23, 2016
7W1M	Cryo-EM structure of human cohesin-CTCF-DNA complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit SA-1, ... 著者 Shi, Z.B, Bai, X.C, Yu, H. 登録日 2021-11-19 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (6.5 Å) 主引用文献 CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol.Cell, 83, 2023
3FQG	Crystal Structure of the S. pombe Rai1 分子名称: MAGNESIUM ION, Protein din1 著者 Xiang, S, Tong, L. 登録日 2009-01-07 公開日 2009-02-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature, 458, 2009
2FNJ	Crystal structure of a B30.2/SPRY domain-containing protein GUSTAVUS in complex with Elongin B and Elongin C 分子名称: CG2944-PF, isoform F, Transcription elongation factor B polypeptide 1, ... 著者 Woo, J.S, Oh, B.H. 登録日 2006-01-11 公開日 2006-03-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and functional insights into the B30.2/SPRY domain Embo J., 25, 2006
4HRH	Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide 分子名称: Helicase-like transcription factor, Protein S100-A10, Annexin A2, ... 著者 Gao, P, Patel, D.J. 登録日 2012-10-27 公開日 2013-03-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.001 Å) 主引用文献 SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action. Cell(Cambridge,Mass.), 152, 2013
4HRG	Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with AHNAK1 Peptide 分子名称: Neuroblast differentiation-associated protein AHNAK, Protein S100-A10 著者 Gao, P, Patel, D.J. 登録日 2012-10-27 公開日 2013-03-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.0001 Å) 主引用文献 SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action. Cell(Cambridge,Mass.), 152, 2013
5O8K	Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895 分子名称: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B 著者 Emamzadah, S, Tropia, L, Huber, F, Halazonetis, T. 登録日 2017-06-13 公開日 2018-06-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895 To Be Published
6ZWM	cryo-EM structure of human mTOR complex 2, overall refinement 分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. 登録日 2020-07-28 公開日 2020-11-18 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
6ZWO	cryo-EM structure of human mTOR complex 2, focused on one half 分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. 登録日 2020-07-28 公開日 2020-11-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
8G87	Human Oct4 bound to nucleosome with human nMatn1 sequence (focused refinement of Oct4 bound region) 分子名称: POU domain, class 5, transcription factor 1, ... 著者 Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. 登録日 2023-02-17 公開日 2023-03-22 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (8.1 Å) 主引用文献 Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
8G8E	Human Oct4 bound to nucleosome with human LIN28B sequence 分子名称: LIN28B DNA (32-MER), POU domain, class 5, ... 著者 Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. 登録日 2023-02-17 公開日 2023-03-22 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
5LLI	pVHL:EloB:EloC in complex with VH298 分子名称: (2~{S},4~{R})-1-[(2~{S})-2-[(1-cyanocyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Soares, P, Galdeano, C, Ciulli, A. 登録日 2016-07-27 公開日 2016-11-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Potent and selective chemical probe of hypoxic signalling downstream of HIF-alpha hydroxylation via VHL inhibition. Nat Commun, 7, 2016
7PY2	Structure of pathological TDP-43 filaments from ALS with FTLD 分子名称: TAR DNA-binding protein 43 著者 Arseni, D, Hasegawa, H, Murzin, A.G, Kametani, F, Arai, M, Yoshida, M, Falcon, B. 登録日 2021-10-08 公開日 2021-12-15 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Structure of pathological TDP-43 filaments from ALS with FTLD. Nature, 601, 2022
5M2N	Crystal Structure of Elongator subunit Elp2 分子名称: Elongator complex protein 2 著者 Glatt, S, Mueller, C.W. 登録日 2016-10-13 公開日 2016-12-28 最終更新日 2017-09-06 実験手法 X-RAY DIFFRACTION (2.812 Å) 主引用文献 Architecture of the yeast Elongator complex. EMBO Rep., 18, 2017
8FVI	Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5 分子名称: Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ... 著者 Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. 登録日 2023-01-19 公開日 2023-09-06 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
7ZZO	HDAC2 in complex with an inhibitor 分子名称: 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-25 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZT	Ligand binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZP	Structure of HDAC2 complexed with an inhibitory ligand 分子名称: (2S)-2-HYDROXYPROPANOIC ACID, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-25 公開日 2022-09-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZR	HDAC2 in complex with inhibitory ligand 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.168 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022

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