5BUH
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![BU of 5buh by Molmil](/molmil-images/mine/5buh) | Influenza PB2 bound to a hydroxymethyl azaindole inhibitor | 分子名称: | N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide, Polymerase basic protein 2 | 著者 | Jacobs, M.D. | 登録日 | 2015-06-03 | 公開日 | 2016-06-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza. ACS Med Chem Lett, 8, 2017
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3FQD
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5HHJ
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7VOI
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![BU of 7voi by Molmil](/molmil-images/mine/7voi) | Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex | 分子名称: | CCR4-NOT transcription complex subunit 1, CCR4-NOT transcription complex subunit 6-like, CCR4-NOT transcription complex subunit 7 | 著者 | Bartlam, M, Zhang, Q. | 登録日 | 2021-10-13 | 公開日 | 2022-06-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (4.38 Å) | 主引用文献 | Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements. Protein Sci., 31, 2022
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6B09
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5IRF
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5IRG
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7W1M
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![BU of 7w1m by Molmil](/molmil-images/mine/7w1m) | Cryo-EM structure of human cohesin-CTCF-DNA complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit SA-1, ... | 著者 | Shi, Z.B, Bai, X.C, Yu, H. | 登録日 | 2021-11-19 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol.Cell, 83, 2023
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3FQG
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![BU of 3fqg by Molmil](/molmil-images/mine/3fqg) | Crystal Structure of the S. pombe Rai1 | 分子名称: | MAGNESIUM ION, Protein din1 | 著者 | Xiang, S, Tong, L. | 登録日 | 2009-01-07 | 公開日 | 2009-02-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature, 458, 2009
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2FNJ
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4HRH
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![BU of 4hrh by Molmil](/molmil-images/mine/4hrh) | Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide | 分子名称: | Helicase-like transcription factor, Protein S100-A10, Annexin A2, ... | 著者 | Gao, P, Patel, D.J. | 登録日 | 2012-10-27 | 公開日 | 2013-03-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | 主引用文献 | SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action. Cell(Cambridge,Mass.), 152, 2013
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4HRG
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5O8K
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6ZWM
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![BU of 6zwm by Molmil](/molmil-images/mine/6zwm) | cryo-EM structure of human mTOR complex 2, overall refinement | 分子名称: | ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. | 登録日 | 2020-07-28 | 公開日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
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6ZWO
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![BU of 6zwo by Molmil](/molmil-images/mine/6zwo) | cryo-EM structure of human mTOR complex 2, focused on one half | 分子名称: | ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. | 登録日 | 2020-07-28 | 公開日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
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8G87
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![BU of 8g87 by Molmil](/molmil-images/mine/8g87) | Human Oct4 bound to nucleosome with human nMatn1 sequence (focused refinement of Oct4 bound region) | 分子名称: | POU domain, class 5, transcription factor 1, ... | 著者 | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | 登録日 | 2023-02-17 | 公開日 | 2023-03-22 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (8.1 Å) | 主引用文献 | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
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8G8E
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![BU of 8g8e by Molmil](/molmil-images/mine/8g8e) | Human Oct4 bound to nucleosome with human LIN28B sequence | 分子名称: | LIN28B DNA (32-MER), POU domain, class 5, ... | 著者 | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | 登録日 | 2023-02-17 | 公開日 | 2023-03-22 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
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5LLI
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![BU of 5lli by Molmil](/molmil-images/mine/5lli) | pVHL:EloB:EloC in complex with VH298 | 分子名称: | (2~{S},4~{R})-1-[(2~{S})-2-[(1-cyanocyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Soares, P, Galdeano, C, Ciulli, A. | 登録日 | 2016-07-27 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Potent and selective chemical probe of hypoxic signalling downstream of HIF-alpha hydroxylation via VHL inhibition. Nat Commun, 7, 2016
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7PY2
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![BU of 7py2 by Molmil](/molmil-images/mine/7py2) | Structure of pathological TDP-43 filaments from ALS with FTLD | 分子名称: | TAR DNA-binding protein 43 | 著者 | Arseni, D, Hasegawa, H, Murzin, A.G, Kametani, F, Arai, M, Yoshida, M, Falcon, B. | 登録日 | 2021-10-08 | 公開日 | 2021-12-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | Structure of pathological TDP-43 filaments from ALS with FTLD. Nature, 601, 2022
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5M2N
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8FVI
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![BU of 8fvi by Molmil](/molmil-images/mine/8fvi) | Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5 | 分子名称: | Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ... | 著者 | Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. | 登録日 | 2023-01-19 | 公開日 | 2023-09-06 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
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7ZZO
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![BU of 7zzo by Molmil](/molmil-images/mine/7zzo) | HDAC2 in complex with an inhibitor | 分子名称: | 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-25 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZT
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![BU of 7zzt by Molmil](/molmil-images/mine/7zzt) | Ligand binding to HDAC2 | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-26 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZP
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![BU of 7zzp by Molmil](/molmil-images/mine/7zzp) | Structure of HDAC2 complexed with an inhibitory ligand | 分子名称: | (2S)-2-HYDROXYPROPANOIC ACID, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-25 | 公開日 | 2022-09-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZR
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![BU of 7zzr by Molmil](/molmil-images/mine/7zzr) | HDAC2 in complex with inhibitory ligand | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-26 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.168 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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