6B09

Crystal structure of HsNUDT16 in complex with diADPR (soaked)

Summary for 6B09

Related5WJI 5W6Z 5W6X 5VY2
DescriptorU8 snoRNA-decapping enzyme, [(2~{R},3~{S},4~{S},5~{S})-5-(6-aminopurin-9-yl)-4-[(2~{S},3~{S},4~{S},5~{S})-5-[[[[(2~{R},3~{R},4~{S},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsnudix hydrolase, decapping enzyme, demodification of parylation, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight44776.51
Authors
Thirawatananond, P.,Gabelli, S.B. (deposition date: 2017-09-14, release date: 2019-01-09, Last modification date: 2019-04-24)
Primary citation
Thirawatananond, P.,McPherson, R.L.,Malhi, J.,Nathan, S.,Lambrecht, M.J.,Brichacek, M.,Hergenrother, P.J.,Leung, A.K.L.,Gabelli, S.B.
Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins.
Sci Rep, 9:5940-5940, 2019
PubMed: 30976021 (PDB entries with the same primary citation)
DOI: 10.1038/s41598-019-39491-w
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.2 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2779 2.9% 5.1% 4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload