7ZZP
Structure of HDAC2 complexed with an inhibitory ligand
Summary for 7ZZP
Entry DOI | 10.2210/pdb7zzp/pdb |
Descriptor | Histone deacetylase 2, DI(HYDROXYETHYL)ETHER, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (13 entities in total) |
Functional Keywords | deacetylase, chromatin binding, transcription regulator, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 172992.50 |
Authors | Cleasby, A.,Tisi, D. (deposition date: 2022-05-25, release date: 2022-09-21, Last modification date: 2023-11-15) |
Primary citation | Tamanini, E.,Miyamura, S.,Buck, I.M.,Cons, B.D.,Dawson, L.,East, C.,Futamura, T.,Goto, S.,Griffiths-Jones, C.,Hashimoto, T.,Heightman, T.D.,Ishikawa, S.,Ito, H.,Kaneko, Y.,Kawato, T.,Kondo, K.,Kurihara, N.,McCarthy, J.M.,Mori, Y.,Nagase, T.,Nakaishi, Y.,Reeks, J.,Sato, A.,Schopf, P.,Tai, K.,Tamai, T.,Tisi, D.,Woolford, A.J. Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13:1591-1597, 2022 Cited by PubMed: 36262388DOI: 10.1021/acsmedchemlett.2c00272 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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