7ZZO

HDAC2 in complex with an inhibitor

Summary for 7ZZO

Entry DOI	10.2210/pdb7zzo/pdb
Descriptor	Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (9 entities in total)
Functional Keywords	histone deacetylase, chromatin binding, protein complex, transcription regulation, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	171313.81
Authors	Cleasby, A.,Tisi, D. (deposition date: 2022-05-25, release date: 2022-09-21, Last modification date: 2022-11-02)
Primary citation	Tamanini, E.,Miyamura, S.,Buck, I.M.,Cons, B.D.,Dawson, L.,East, C.,Futamura, T.,Goto, S.,Griffiths-Jones, C.,Hashimoto, T.,Heightman, T.D.,Ishikawa, S.,Ito, H.,Kaneko, Y.,Kawato, T.,Kondo, K.,Kurihara, N.,McCarthy, J.M.,Mori, Y.,Nagase, T.,Nakaishi, Y.,Reeks, J.,Sato, A.,Schopf, P.,Tai, K.,Tamai, T.,Tisi, D.,Woolford, A.J. Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13:1591-1597, 2022 Cited by PubMed: 36262388 DOI: 10.1021/acsmedchemlett.2c00272 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation