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7ZZO

HDAC2 in complex with an inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0001975biological_processresponse to amphetamine
A0003300biological_processcardiac muscle hypertrophy
A0003682molecular_functionchromatin binding
A0003723molecular_functionRNA binding
A0004407molecular_functionhistone deacetylase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0009913biological_processepidermal cell differentiation
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010944biological_processnegative regulation of transcription by competitive promoter binding
A0010977biological_processnegative regulation of neuron projection development
A0016358biological_processdendrite development
A0016581cellular_componentNuRD complex
A0016787molecular_functionhydrolase activity
A0019213molecular_functiondeacetylase activity
A0019899molecular_functionenzyme binding
A0030336biological_processnegative regulation of cell migration
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031000biological_processresponse to caffeine
A0031072molecular_functionheat shock protein binding
A0031078molecular_functionhistone H3K14 deacetylase activity, hydrolytic mechanism
A0031492molecular_functionnucleosomal DNA binding
A0031507biological_processheterochromatin formation
A0032129molecular_functionhistone H3K9 deacetylase activity, hydrolytic mechanism
A0032496biological_processresponse to lipopolysaccharide
A0032732biological_processpositive regulation of interleukin-1 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032922biological_processcircadian regulation of gene expression
A0032967biological_processpositive regulation of collagen biosynthetic process
A0032991cellular_componentprotein-containing complex
A0033558molecular_functionprotein lysine deacetylase activity
A0034605biological_processcellular response to heat
A0034739molecular_functionhistone H4K16 deacetylase activity, hydrolytic mechanism
A0035094biological_processresponse to nicotine
A0035098cellular_componentESC/E(Z) complex
A0036211biological_processprotein modification process
A0042220biological_processresponse to cocaine
A0042393molecular_functionhistone binding
A0042475biological_processodontogenesis of dentin-containing tooth
A0042659biological_processregulation of cell fate specification
A0042733biological_processembryonic digit morphogenesis
A0042826molecular_functionhistone deacetylase binding
A0042903molecular_functiontubulin deacetylase activity
A0043066biological_processnegative regulation of apoptotic process
A0043433biological_processnegative regulation of DNA-binding transcription factor activity
A0045347biological_processnegative regulation of MHC class II biosynthetic process
A0045862biological_processpositive regulation of proteolysis
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048149biological_processbehavioral response to ethanol
A0048511biological_processrhythmic process
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0051059molecular_functionNF-kappaB binding
A0055093biological_processresponse to hyperoxia
A0060789biological_processhair follicle placode formation
A0061000biological_processnegative regulation of dendritic spine development
A0061029biological_processeyelid development in camera-type eye
A0061198biological_processfungiform papilla formation
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070301biological_processcellular response to hydrogen peroxide
A0070822cellular_componentSin3-type complex
A0071300biological_processcellular response to retinoic acid
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0097305biological_processresponse to alcohol
A0140297molecular_functionDNA-binding transcription factor binding
A0140937molecular_functionhistone H4K12 deacetylase activity, hydrolytic mechanism
A0160008molecular_functionprotein decrotonylase activity
A0160009molecular_functionhistone decrotonylase activity
A0160010molecular_functionprotein de-2-hydroxyisobutyrylase activity
A0160216molecular_functionprotein lysine delactylase activity
A0180032molecular_functionhistone H4K5 deacetylase activity, hydrolytic mechanism
A0180033molecular_functionhistone H4K8 deacetylase activity, hydrolytic mechanism
A1902437biological_processpositive regulation of male mating behavior
A1902455biological_processnegative regulation of stem cell population maintenance
A1902459biological_processpositive regulation of stem cell population maintenance
A1903351biological_processcellular response to dopamine
A1904645biological_processresponse to amyloid-beta
A1990162molecular_functionhistone H3K4 deacetylase activity, hydrolytic mechanism
A1990841molecular_functionpromoter-specific chromatin binding
A2000273biological_processpositive regulation of signaling receptor activity
A2000736biological_processregulation of stem cell differentiation
A2000757biological_processnegative regulation of peptidyl-lysine acetylation
B0000118cellular_componenthistone deacetylase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0001975biological_processresponse to amphetamine
B0003300biological_processcardiac muscle hypertrophy
B0003682molecular_functionchromatin binding
B0003723molecular_functionRNA binding
B0004407molecular_functionhistone deacetylase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0008284biological_processpositive regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0009913biological_processepidermal cell differentiation
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010944biological_processnegative regulation of transcription by competitive promoter binding
B0010977biological_processnegative regulation of neuron projection development
B0016358biological_processdendrite development
B0016581cellular_componentNuRD complex
B0016787molecular_functionhydrolase activity
B0019213molecular_functiondeacetylase activity
B0019899molecular_functionenzyme binding
B0030336biological_processnegative regulation of cell migration
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0031000biological_processresponse to caffeine
B0031072molecular_functionheat shock protein binding
B0031078molecular_functionhistone H3K14 deacetylase activity, hydrolytic mechanism
B0031492molecular_functionnucleosomal DNA binding
B0031507biological_processheterochromatin formation
B0032129molecular_functionhistone H3K9 deacetylase activity, hydrolytic mechanism
B0032496biological_processresponse to lipopolysaccharide
B0032732biological_processpositive regulation of interleukin-1 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032922biological_processcircadian regulation of gene expression
B0032967biological_processpositive regulation of collagen biosynthetic process
B0032991cellular_componentprotein-containing complex
B0033558molecular_functionprotein lysine deacetylase activity
B0034605biological_processcellular response to heat
B0034739molecular_functionhistone H4K16 deacetylase activity, hydrolytic mechanism
B0035094biological_processresponse to nicotine
B0035098cellular_componentESC/E(Z) complex
B0036211biological_processprotein modification process
B0042220biological_processresponse to cocaine
B0042393molecular_functionhistone binding
B0042475biological_processodontogenesis of dentin-containing tooth
B0042659biological_processregulation of cell fate specification
B0042733biological_processembryonic digit morphogenesis
B0042826molecular_functionhistone deacetylase binding
B0042903molecular_functiontubulin deacetylase activity
B0043066biological_processnegative regulation of apoptotic process
B0043433biological_processnegative regulation of DNA-binding transcription factor activity
B0045347biological_processnegative regulation of MHC class II biosynthetic process
B0045862biological_processpositive regulation of proteolysis
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048149biological_processbehavioral response to ethanol
B0048511biological_processrhythmic process
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0051059molecular_functionNF-kappaB binding
B0055093biological_processresponse to hyperoxia
B0060789biological_processhair follicle placode formation
B0061000biological_processnegative regulation of dendritic spine development
B0061029biological_processeyelid development in camera-type eye
B0061198biological_processfungiform papilla formation
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070301biological_processcellular response to hydrogen peroxide
B0070822cellular_componentSin3-type complex
B0071300biological_processcellular response to retinoic acid
B0071560biological_processcellular response to transforming growth factor beta stimulus
B0097305biological_processresponse to alcohol
B0140297molecular_functionDNA-binding transcription factor binding
B0140937molecular_functionhistone H4K12 deacetylase activity, hydrolytic mechanism
B0160008molecular_functionprotein decrotonylase activity
B0160009molecular_functionhistone decrotonylase activity
B0160010molecular_functionprotein de-2-hydroxyisobutyrylase activity
B0160216molecular_functionprotein lysine delactylase activity
B0180032molecular_functionhistone H4K5 deacetylase activity, hydrolytic mechanism
B0180033molecular_functionhistone H4K8 deacetylase activity, hydrolytic mechanism
B1902437biological_processpositive regulation of male mating behavior
B1902455biological_processnegative regulation of stem cell population maintenance
B1902459biological_processpositive regulation of stem cell population maintenance
B1903351biological_processcellular response to dopamine
B1904645biological_processresponse to amyloid-beta
B1990162molecular_functionhistone H3K4 deacetylase activity, hydrolytic mechanism
B1990841molecular_functionpromoter-specific chromatin binding
B2000273biological_processpositive regulation of signaling receptor activity
B2000736biological_processregulation of stem cell differentiation
B2000757biological_processnegative regulation of peptidyl-lysine acetylation
C0000118cellular_componenthistone deacetylase complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0001975biological_processresponse to amphetamine
C0003300biological_processcardiac muscle hypertrophy
C0003682molecular_functionchromatin binding
C0003723molecular_functionRNA binding
C0004407molecular_functionhistone deacetylase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0008284biological_processpositive regulation of cell population proliferation
C0009410biological_processresponse to xenobiotic stimulus
C0009913biological_processepidermal cell differentiation
C0010718biological_processpositive regulation of epithelial to mesenchymal transition
C0010944biological_processnegative regulation of transcription by competitive promoter binding
C0010977biological_processnegative regulation of neuron projection development
C0016358biological_processdendrite development
C0016581cellular_componentNuRD complex
C0016787molecular_functionhydrolase activity
C0019213molecular_functiondeacetylase activity
C0019899molecular_functionenzyme binding
C0030336biological_processnegative regulation of cell migration
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0031000biological_processresponse to caffeine
C0031072molecular_functionheat shock protein binding
C0031078molecular_functionhistone H3K14 deacetylase activity, hydrolytic mechanism
C0031492molecular_functionnucleosomal DNA binding
C0031507biological_processheterochromatin formation
C0032129molecular_functionhistone H3K9 deacetylase activity, hydrolytic mechanism
C0032496biological_processresponse to lipopolysaccharide
C0032732biological_processpositive regulation of interleukin-1 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032922biological_processcircadian regulation of gene expression
C0032967biological_processpositive regulation of collagen biosynthetic process
C0032991cellular_componentprotein-containing complex
C0033558molecular_functionprotein lysine deacetylase activity
C0034605biological_processcellular response to heat
C0034739molecular_functionhistone H4K16 deacetylase activity, hydrolytic mechanism
C0035094biological_processresponse to nicotine
C0035098cellular_componentESC/E(Z) complex
C0036211biological_processprotein modification process
C0042220biological_processresponse to cocaine
C0042393molecular_functionhistone binding
C0042475biological_processodontogenesis of dentin-containing tooth
C0042659biological_processregulation of cell fate specification
C0042733biological_processembryonic digit morphogenesis
C0042826molecular_functionhistone deacetylase binding
C0042903molecular_functiontubulin deacetylase activity
C0043066biological_processnegative regulation of apoptotic process
C0043433biological_processnegative regulation of DNA-binding transcription factor activity
C0045347biological_processnegative regulation of MHC class II biosynthetic process
C0045862biological_processpositive regulation of proteolysis
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048149biological_processbehavioral response to ethanol
C0048511biological_processrhythmic process
C0048714biological_processpositive regulation of oligodendrocyte differentiation
C0051059molecular_functionNF-kappaB binding
C0055093biological_processresponse to hyperoxia
C0060789biological_processhair follicle placode formation
C0061000biological_processnegative regulation of dendritic spine development
C0061029biological_processeyelid development in camera-type eye
C0061198biological_processfungiform papilla formation
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0070301biological_processcellular response to hydrogen peroxide
C0070822cellular_componentSin3-type complex
C0071300biological_processcellular response to retinoic acid
C0071560biological_processcellular response to transforming growth factor beta stimulus
C0097305biological_processresponse to alcohol
C0140297molecular_functionDNA-binding transcription factor binding
C0140937molecular_functionhistone H4K12 deacetylase activity, hydrolytic mechanism
C0160008molecular_functionprotein decrotonylase activity
C0160009molecular_functionhistone decrotonylase activity
C0160010molecular_functionprotein de-2-hydroxyisobutyrylase activity
C0160216molecular_functionprotein lysine delactylase activity
C0180032molecular_functionhistone H4K5 deacetylase activity, hydrolytic mechanism
C0180033molecular_functionhistone H4K8 deacetylase activity, hydrolytic mechanism
C1902437biological_processpositive regulation of male mating behavior
C1902455biological_processnegative regulation of stem cell population maintenance
C1902459biological_processpositive regulation of stem cell population maintenance
C1903351biological_processcellular response to dopamine
C1904645biological_processresponse to amyloid-beta
C1990162molecular_functionhistone H3K4 deacetylase activity, hydrolytic mechanism
C1990841molecular_functionpromoter-specific chromatin binding
C2000273biological_processpositive regulation of signaling receptor activity
C2000736biological_processregulation of stem cell differentiation
C2000757biological_processnegative regulation of peptidyl-lysine acetylation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q13547
ChainResidueDetails
AHIS146
BHIS146
CHIS146

site_idSWS_FT_FI2
Number of Residues27
DetailsBINDING: BINDING => ECO:0000269|PubMed:37137925, ECO:0007744|PDB:8BPA, ECO:0007744|PDB:8BPB, ECO:0007744|PDB:8BPC
ChainResidueDetails
AASP179
BASP179
BASP181
BHIS183
BPHE192
BTHR195
BVAL198
BSER202
BPHE203
BASP269
CASP179
AASP181
CASP181
CHIS183
CPHE192
CTHR195
CVAL198
CSER202
CPHE203
CASP269
AHIS183
APHE192
ATHR195
AVAL198
ASER202
APHE203
AASP269

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:37137925, ECO:0007744|PDB:8BPB, ECO:0007744|PDB:8BPC
ChainResidueDetails
ATYR227
BTYR227
CTYR227

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q13547
ChainResidueDetails
ALYS79
BLYS79
CLYS79

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q13547
ChainResidueDetails
ALYS225
BLYS225
CLYS225

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P70288
ChainResidueDetails
ACYS266
ACYS278
BCYS266
BCYS278
CCYS266
CCYS278

site_idSWS_FT_FI7
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER398
BSER398
CSER398

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER411
BSER411
CSER411

site_idSWS_FT_FI9
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER426
BSER426
CSER426

site_idSWS_FT_FI10
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER428
BSER428
CSER428

site_idSWS_FT_FI11
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS79
BLYS79
CLYS79

site_idSWS_FT_FI12
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS485
BLYS485
CLYS485

site_idSWS_FT_FI13
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:Q13547
ChainResidueDetails
ALYS443
BLYS443
CLYS443

site_idSWS_FT_FI14
Number of Residues9
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS456
ALYS462
ALYS482
BLYS456
BLYS462
BLYS482
CLYS456
CLYS462
CLYS482

site_idSWS_FT_FI15
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS466
BLYS466
CLYS466

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PDB entries from 2024-11-20

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