7ZZO

HDAC2 in complex with an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001221	molecular_function	transcription coregulator binding
A	0001975	biological_process	response to amphetamine
A	0003300	biological_process	cardiac muscle hypertrophy
A	0003682	molecular_function	chromatin binding
A	0003723	molecular_function	RNA binding
A	0004407	molecular_function	histone deacetylase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009410	biological_process	response to xenobiotic stimulus
A	0009913	biological_process	epidermal cell differentiation
A	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
A	0010944	biological_process	negative regulation of transcription by competitive promoter binding
A	0010977	biological_process	negative regulation of neuron projection development
A	0016358	biological_process	dendrite development
A	0016581	cellular_component	NuRD complex
A	0016787	molecular_function	hydrolase activity
A	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
A	0019213	molecular_function	deacetylase activity
A	0019899	molecular_function	enzyme binding
A	0030336	biological_process	negative regulation of cell migration
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0031000	biological_process	response to caffeine
A	0031072	molecular_function	heat shock protein binding
A	0031492	molecular_function	nucleosomal DNA binding
A	0031507	biological_process	heterochromatin formation
A	0032496	biological_process	response to lipopolysaccharide
A	0032732	biological_process	positive regulation of interleukin-1 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0032922	biological_process	circadian regulation of gene expression
A	0032991	cellular_component	protein-containing complex
A	0033148	biological_process	positive regulation of intracellular estrogen receptor signaling pathway
A	0033558	molecular_function	protein lysine deacetylase activity
A	0034605	biological_process	cellular response to heat
A	0035094	biological_process	response to nicotine
A	0035098	cellular_component	ESC/E(Z) complex
A	0036211	biological_process	protein modification process
A	0042220	biological_process	response to cocaine
A	0042393	molecular_function	histone binding
A	0042475	biological_process	odontogenesis of dentin-containing tooth
A	0042659	biological_process	regulation of cell fate specification
A	0042733	biological_process	embryonic digit morphogenesis
A	0042826	molecular_function	histone deacetylase binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0045862	biological_process	positive regulation of proteolysis
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048149	biological_process	behavioral response to ethanol
A	0048511	biological_process	rhythmic process
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0050847	biological_process	progesterone receptor signaling pathway
A	0051059	molecular_function	NF-kappaB binding
A	0055093	biological_process	response to hyperoxia
A	0060789	biological_process	hair follicle placode formation
A	0061000	biological_process	negative regulation of dendritic spine development
A	0061029	biological_process	eyelid development in camera-type eye
A	0061198	biological_process	fungiform papilla formation
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070822	cellular_component	Sin3-type complex
A	0071300	biological_process	cellular response to retinoic acid
A	0071560	biological_process	cellular response to transforming growth factor beta stimulus
A	0097305	biological_process	response to alcohol
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
A	0160008	molecular_function	protein decrotonylase activity
A	0160009	molecular_function	histone decrotonylase activity
A	0160010	molecular_function	protein de-2-hydroxyisobutyrylase activity
A	0160216	molecular_function	protein lysine delactylase activity
A	1902437	biological_process	positive regulation of male mating behavior
A	1902455	biological_process	negative regulation of stem cell population maintenance
A	1902459	biological_process	positive regulation of stem cell population maintenance
A	1903351	biological_process	cellular response to dopamine
A	1904645	biological_process	response to amyloid-beta
A	1990841	molecular_function	promoter-specific chromatin binding
A	2000736	biological_process	regulation of stem cell differentiation
B	0000118	cellular_component	histone deacetylase complex
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0001221	molecular_function	transcription coregulator binding
B	0001975	biological_process	response to amphetamine
B	0003300	biological_process	cardiac muscle hypertrophy
B	0003682	molecular_function	chromatin binding
B	0003723	molecular_function	RNA binding
B	0004407	molecular_function	histone deacetylase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009410	biological_process	response to xenobiotic stimulus
B	0009913	biological_process	epidermal cell differentiation
B	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
B	0010944	biological_process	negative regulation of transcription by competitive promoter binding
B	0010977	biological_process	negative regulation of neuron projection development
B	0016358	biological_process	dendrite development
B	0016581	cellular_component	NuRD complex
B	0016787	molecular_function	hydrolase activity
B	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
B	0019213	molecular_function	deacetylase activity
B	0019899	molecular_function	enzyme binding
B	0030336	biological_process	negative regulation of cell migration
B	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
B	0031000	biological_process	response to caffeine
B	0031072	molecular_function	heat shock protein binding
B	0031492	molecular_function	nucleosomal DNA binding
B	0031507	biological_process	heterochromatin formation
B	0032496	biological_process	response to lipopolysaccharide
B	0032732	biological_process	positive regulation of interleukin-1 production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0032922	biological_process	circadian regulation of gene expression
B	0032991	cellular_component	protein-containing complex
B	0033148	biological_process	positive regulation of intracellular estrogen receptor signaling pathway
B	0033558	molecular_function	protein lysine deacetylase activity
B	0034605	biological_process	cellular response to heat
B	0035094	biological_process	response to nicotine
B	0035098	cellular_component	ESC/E(Z) complex
B	0036211	biological_process	protein modification process
B	0042220	biological_process	response to cocaine
B	0042393	molecular_function	histone binding
B	0042475	biological_process	odontogenesis of dentin-containing tooth
B	0042659	biological_process	regulation of cell fate specification
B	0042733	biological_process	embryonic digit morphogenesis
B	0042826	molecular_function	histone deacetylase binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0045862	biological_process	positive regulation of proteolysis
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0048149	biological_process	behavioral response to ethanol
B	0048511	biological_process	rhythmic process
B	0048714	biological_process	positive regulation of oligodendrocyte differentiation
B	0050847	biological_process	progesterone receptor signaling pathway
B	0051059	molecular_function	NF-kappaB binding
B	0055093	biological_process	response to hyperoxia
B	0060789	biological_process	hair follicle placode formation
B	0061000	biological_process	negative regulation of dendritic spine development
B	0061029	biological_process	eyelid development in camera-type eye
B	0061198	biological_process	fungiform papilla formation
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0070822	cellular_component	Sin3-type complex
B	0071300	biological_process	cellular response to retinoic acid
B	0071560	biological_process	cellular response to transforming growth factor beta stimulus
B	0097305	biological_process	response to alcohol
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
B	0160008	molecular_function	protein decrotonylase activity
B	0160009	molecular_function	histone decrotonylase activity
B	0160010	molecular_function	protein de-2-hydroxyisobutyrylase activity
B	0160216	molecular_function	protein lysine delactylase activity
B	1902437	biological_process	positive regulation of male mating behavior
B	1902455	biological_process	negative regulation of stem cell population maintenance
B	1902459	biological_process	positive regulation of stem cell population maintenance
B	1903351	biological_process	cellular response to dopamine
B	1904645	biological_process	response to amyloid-beta
B	1990841	molecular_function	promoter-specific chromatin binding
B	2000736	biological_process	regulation of stem cell differentiation
C	0000118	cellular_component	histone deacetylase complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0001221	molecular_function	transcription coregulator binding
C	0001975	biological_process	response to amphetamine
C	0003300	biological_process	cardiac muscle hypertrophy
C	0003682	molecular_function	chromatin binding
C	0003723	molecular_function	RNA binding
C	0004407	molecular_function	histone deacetylase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009410	biological_process	response to xenobiotic stimulus
C	0009913	biological_process	epidermal cell differentiation
C	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
C	0010944	biological_process	negative regulation of transcription by competitive promoter binding
C	0010977	biological_process	negative regulation of neuron projection development
C	0016358	biological_process	dendrite development
C	0016581	cellular_component	NuRD complex
C	0016787	molecular_function	hydrolase activity
C	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
C	0019213	molecular_function	deacetylase activity
C	0019899	molecular_function	enzyme binding
C	0030336	biological_process	negative regulation of cell migration
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0031000	biological_process	response to caffeine
C	0031072	molecular_function	heat shock protein binding
C	0031492	molecular_function	nucleosomal DNA binding
C	0031507	biological_process	heterochromatin formation
C	0032496	biological_process	response to lipopolysaccharide
C	0032732	biological_process	positive regulation of interleukin-1 production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0032922	biological_process	circadian regulation of gene expression
C	0032991	cellular_component	protein-containing complex
C	0033148	biological_process	positive regulation of intracellular estrogen receptor signaling pathway
C	0033558	molecular_function	protein lysine deacetylase activity
C	0034605	biological_process	cellular response to heat
C	0035094	biological_process	response to nicotine
C	0035098	cellular_component	ESC/E(Z) complex
C	0036211	biological_process	protein modification process
C	0042220	biological_process	response to cocaine
C	0042393	molecular_function	histone binding
C	0042475	biological_process	odontogenesis of dentin-containing tooth
C	0042659	biological_process	regulation of cell fate specification
C	0042733	biological_process	embryonic digit morphogenesis
C	0042826	molecular_function	histone deacetylase binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0045862	biological_process	positive regulation of proteolysis
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048149	biological_process	behavioral response to ethanol
C	0048511	biological_process	rhythmic process
C	0048714	biological_process	positive regulation of oligodendrocyte differentiation
C	0050847	biological_process	progesterone receptor signaling pathway
C	0051059	molecular_function	NF-kappaB binding
C	0055093	biological_process	response to hyperoxia
C	0060789	biological_process	hair follicle placode formation
C	0061000	biological_process	negative regulation of dendritic spine development
C	0061029	biological_process	eyelid development in camera-type eye
C	0061198	biological_process	fungiform papilla formation
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0070822	cellular_component	Sin3-type complex
C	0071300	biological_process	cellular response to retinoic acid
C	0071560	biological_process	cellular response to transforming growth factor beta stimulus
C	0097305	biological_process	response to alcohol
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
C	0160008	molecular_function	protein decrotonylase activity
C	0160009	molecular_function	histone decrotonylase activity
C	0160010	molecular_function	protein de-2-hydroxyisobutyrylase activity
C	0160216	molecular_function	protein lysine delactylase activity
C	1902437	biological_process	positive regulation of male mating behavior
C	1902455	biological_process	negative regulation of stem cell population maintenance
C	1902459	biological_process	positive regulation of stem cell population maintenance
C	1903351	biological_process	cellular response to dopamine
C	1904645	biological_process	response to amyloid-beta
C	1990841	molecular_function	promoter-specific chromatin binding
C	2000736	biological_process	regulation of stem cell differentiation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	626
Details	Region: {"description":"Histone deacetylase"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q13547","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O15379","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	27
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37137925","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8BPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8BPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8BPC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37137925","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8BPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8BPC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q13547","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13547","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P70288","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---