7ZZO

HDAC2 in complex with an inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Histone deacetylase 2	polymer	498	56560.3	3	UniProt (Q92769) Pfam (PF00850) In PDB	Homo sapiens (human)	HD2,Protein deacylase HDAC2
2	A, B, C	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
3	A, B, C	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
4	A, B, C	SODIUM ION	non-polymer		23.0	3	Chemie (NA)
5	A, B, C	[(2~{R})-1-(dimethylamino)-3-(4-fluorophenyl)-1-oxidanylidene-propan-2-yl]azanium	non-polymer		211.3	3	Chemie (KIZ)
6	B	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
7	B, C	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
8	B	2-(cyclohexylazaniumyl)ethanesulfonate	non-polymer		207.3	1	Chemie (KZF)
9		water	water		18.0	807	Chemie (HOH)

Sequence modifications

A, B, C: 5 - 492 (UniProt: Q92769)

PDB	External Database	Details
Gly 493	-	expression tag
Ser 494	-	expression tag
Ser 495	-	expression tag
Gly 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag
His 502	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	169680.9
Non-Polymers*	Number of molecules	16
	Total formula weight	1633.0
All*	Total formula weight	171313.8

*Water molecules are not included.