7U2K
 
 | | C6-guano bound Mu Opioid Receptor-Gi Protein Complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Wang, H, Kobilka, B. | | 登録日 | 2022-02-24 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-02-08 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure-based design of bitopic ligands for the μ-opioid receptor.
Nature, 613, 2023
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7TZF
 | | Human Amylin3 Receptor in complex with Gs and rat amylin peptide | | 分子名称: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-15 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TYY
 | | Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-14 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TYX
 | | Human Amylin2 Receptor in complex with Gs and rat amylin peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-14 | | 公開日 | 2022-03-30 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TYW
 | | Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-14 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TYO
 | | Calcitonin receptor in complex with Gs and human calcitonin peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-14 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TYN
 | | Calcitonin Receptor in complex with Gs and salmon calcitonin peptide | | 分子名称: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-13 | | 公開日 | 2022-03-30 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TYL
 | | Calcitonin Receptor in complex with Gs and rat amylin peptide, bypass motif | | 分子名称: | Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-13 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TYI
 | | Calcitonin Receptor in complex with Gs and rat amylin peptide, CT-like state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-13 | | 公開日 | 2022-03-30 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TYH
 | | Human Amylin2 Receptor in complex with Gs and human calcitonin peptide | | 分子名称: | Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-13 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TYF
 | | Human Amylin1 Receptor in complex with Gs and rat amylin peptide | | 分子名称: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | | 登録日 | 2022-02-13 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | A structural basis for amylin receptor phenotype.
Science, 375, 2022
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7TUZ
 | | Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein | | 分子名称: | (2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol, G-protein coupled receptor 183, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Chen, H, Hung, W, Li, X. | | 登録日 | 2022-02-03 | | 公開日 | 2022-04-13 | | 最終更新日 | 2022-07-20 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.
Structure, 30, 2022
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7TRS
 | | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine | | 分子名称: | ACETYLCHOLINE, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | | 登録日 | 2022-01-30 | | 公開日 | 2023-05-17 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor
Elife, 2023
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7TRQ
 | | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154 | | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide, Antibody fragment scFv16, ... | | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | | 登録日 | 2022-01-30 | | 公開日 | 2023-05-17 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor
Elife, 2023
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7TRP
 | | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298 | | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ... | | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | | 登録日 | 2022-01-30 | | 公開日 | 2023-05-17 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor
Elife, 2023
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7TRK
 | | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo | | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | | 登録日 | 2022-01-29 | | 公開日 | 2023-05-17 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor
Elife, 2023
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7TMW
 | | Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs | | 分子名称: | Camelid antibody VHH fragment Nb35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Erlandson, S.C, Rawson, S, Kruse, A.C. | | 登録日 | 2022-01-20 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The relaxin receptor RXFP1 signals through a mechanism of autoinhibition.
Nat.Chem.Biol., 19, 2023
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7TD4
 | | Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod | | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | | 登録日 | 2021-12-30 | | 公開日 | 2022-02-09 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
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7TD3
 | | Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P | | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | | 登録日 | 2021-12-30 | | 公開日 | 2022-02-09 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
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7TD2
 | | Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a | | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | | 登録日 | 2021-12-30 | | 公開日 | 2022-02-09 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
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7TD1
 | | Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a | | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | | 登録日 | 2021-12-30 | | 公開日 | 2022-02-09 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
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7TD0
 | | Lysophosphatidic acid receptor 1-Gi complex bound to LPA | | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | | 登録日 | 2021-12-30 | | 公開日 | 2022-02-09 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
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7T9N
 | | M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure) | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Faust, B, Cheng, Y, Manglik, A. | | 登録日 | 2021-12-19 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
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7T9I
 | | Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain, ... | | 著者 | Faust, B, Cheng, Y, Manglik, A. | | 登録日 | 2021-12-19 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
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7T96
 | | Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM | | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | | 登録日 | 2021-12-18 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nat Commun, 14, 2023
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