5L6I
 
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5L8H
 | | Structure of USP46-UbVME | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, ZINC ION | | 著者 | Clerici, M, Sixma, T, Dharadhar, S. | | 登録日 | 2016-06-07 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
J.Struct.Biol., 196, 2016
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5L6J
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5KYD
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5LN1
 | | STRUCTURE OF UBIQUITYLATED-RPN10 FROM YEAST; | | 分子名称: | 26S proteasome regulatory subunit RPN10, Polyubiquitin-B | | 著者 | Keren-Kaplan, T, Attali, I, Levin-Kravets, O, Prag, G. | | 登録日 | 2016-08-02 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | | 主引用文献 | Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism.
Nat Commun, 7, 2016
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5LLI
 | | pVHL:EloB:EloC in complex with VH298 | | 分子名称: | (2~{S},4~{R})-1-[(2~{S})-2-[(1-cyanocyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | | 著者 | Gadd, M.S, Soares, P, Galdeano, C, Ciulli, A. | | 登録日 | 2016-07-27 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Potent and selective chemical probe of hypoxic signalling downstream of HIF-alpha hydroxylation via VHL inhibition.
Nat Commun, 7, 2016
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5LRW
 | | Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin | | 分子名称: | GLYCEROL, OTU domain-containing protein 7B, Polyubiquitin-B | | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | 登録日 | 2016-08-22 | | 公開日 | 2016-10-19 | | 最終更新日 | 2017-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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5LRX
 | | Structure of A20 OTU domain bound to ubiquitin | | 分子名称: | Polyubiquitin-B, Tumor necrosis factor alpha-induced protein 3 | | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | 登録日 | 2016-08-22 | | 公開日 | 2016-10-19 | | 最終更新日 | 2017-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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5N2W
 | | WT-Parkin and pUB complex | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ... | | 著者 | Kumar, A, Chaugule, V.K, Johnson, C, Toth, R, Sundaramoorthy, R, Knebel, A, Walden, H. | | 登録日 | 2017-02-08 | | 公開日 | 2017-04-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
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5LRV
 | | Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin | | 分子名称: | GLYCEROL, OTU domain-containing protein 7B, PHOSPHATE ION, ... | | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | 登録日 | 2016-08-22 | | 公開日 | 2016-10-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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5N38
 | | S65DParkin and pUB complex | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, ... | | 著者 | Kumar, A, Chaugule, V.K, Johnson, C, Toth, R, Sundaramoorthy, R, Knebel, A, Walden, H. | | 登録日 | 2017-02-08 | | 公開日 | 2017-04-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
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4ZFR
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4ZFT
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6EI1
 | | Crystal structure of the covalent complex between deubiquitinase ZUFSP (ZUP1) and Ubiquitin-PA | | 分子名称: | GLYCEROL, MALONATE ION, Polyubiquitin-B, ... | | 著者 | Pichlo, C, Baumann, U, Hofmann, K, Hermanns, T. | | 登録日 | 2017-09-16 | | 公開日 | 2018-03-07 | | 最終更新日 | 2019-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.732 Å) | | 主引用文献 | A family of unconventional deubiquitinases with modular chain specificity determinants.
Nat Commun, 9, 2018
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5BZ0
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6FGE
 | | Crystal structure of human ZUFSP/ZUP1 in complex with ubiquitin | | 分子名称: | ACETATE ION, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Kwasna, D, Abdul Rehman, S.A, Kulathu, Y. | | 登録日 | 2018-01-10 | | 公開日 | 2018-04-04 | | 最終更新日 | 2018-04-18 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.
Mol. Cell, 70, 2018
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5AF6
 | | Structure of Lys33-linked diUb bound to Trabid NZF1 | | 分子名称: | TRABID, UBIQUITIN, ZINC ION | | 著者 | Michel, M.A, Elliott, P.R, Swatek, K.N, Simicek, M, Pruneda, J.N, Wagstaff, J.L, Freund, S.M.V, Komander, D. | | 登録日 | 2015-01-19 | | 公開日 | 2015-03-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin.
Mol.Cell, 58, 2015
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5CHV
 | | Crystal structure of USP18-ISG15 complex | | 分子名称: | CHLORIDE ION, SULFATE ION, Ubiquitin-like protein ISG15, ... | | 著者 | Fritz, G, Basters, A. | | 登録日 | 2015-07-10 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.005 Å) | | 主引用文献 | Structural basis of the specificity of USP18 toward ISG15.
Nat. Struct. Mol. Biol., 24, 2017
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6FNO
 | | Caldiarchaeum Subterraneum Ubiquitin:Rpn11-homolog complex, zinc soak | | 分子名称: | 26S proteasome regulatory subunit N11-like protein, SULFATE ION, Ubiquitin-like protein, ... | | 著者 | Fuchs, A.C.D, Albrecht, R, Martin, J, Hartmann, M.D. | | 登録日 | 2018-02-04 | | 公開日 | 2018-07-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Rpn11-mediated ubiquitin processing in an ancestral archaeal ubiquitination system.
Nat Commun, 9, 2018
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5B83
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5C1Z
 | | Parkin (UblR0RBR) | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | | 著者 | kumar, A, Aguirre, J.D, Condos, T.E.C, Martinez-Torres, R.J, Chaugule, V.K, Toth, R, Sundaramoorthy, R, Mercier, P, Knebel, A, Spratt, D.E, Barber, K.R, Shaw, G.S, Walden, H. | | 登録日 | 2015-06-15 | | 公開日 | 2015-07-29 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
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5C7J
 | | CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT | | 分子名称: | E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C | | 著者 | Walker, J.R, Hu, J, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | | 登録日 | 2015-06-24 | | 公開日 | 2016-03-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
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6FMK
 | | pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4) | | 分子名称: | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... | | 著者 | Soares, P, Lucas, X, Ciulli, A. | | 登録日 | 2018-01-31 | | 公開日 | 2018-04-11 | | 最終更新日 | 2018-06-20 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.
Bioorg. Med. Chem., 26, 2018
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6FNN
 | | Caldiarchaeum Subterraneum Ubiquitin:Rpn11-homolog complex | | 分子名称: | 26S proteasome regulatory subunit N11-like protein, SULFATE ION, Ubiquitin-like protein, ... | | 著者 | Fuchs, A.C.D, Albrecht, R, Martin, J, Hartmann, M.D. | | 登録日 | 2018-02-04 | | 公開日 | 2018-07-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Rpn11-mediated ubiquitin processing in an ancestral archaeal ubiquitination system.
Nat Commun, 9, 2018
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6FX4
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