PDB: 1146 件ウェブページステータス検索Chemie searchBIRD

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1PX6	A folding mutant of human class pi glutathione transferase, created by mutating aspartate 153 of the wild-type protein to asparagine 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, Glutathione S-transferase P 著者 Kong, G.K.-W, Polekhina, G, McKinstry, W.J, Parker, M.W, Dragani, B, Aceto, A, Paludi, D, Principe, D.R, Mannervik, B, Stenberg, G. 登録日 2003-07-02 公開日 2003-07-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The multi-functional role of a highly conserved aspartic acid residue in glutathione transferase P1-1 To be Published
1PX7	A folding mutant of human class pi glutathione transferase, created by mutating aspartate 153 of the wild-type protein to glutamate 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLUTATHIONE, ... 著者 Kong, G.K.-W, Polekhina, G, McKinstry, W.J, Parker, M.W, Dragani, B, Aceto, A, Paludi, D, Principe, D.R, Mannervik, B, Stenberg, G. 登録日 2003-07-02 公開日 2003-07-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 The multi-functional role of a highly conserved aspartic acid residue in glutathione transferase P1-1 To be Published
2Z1B	Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs 分子名称: Delta-aminolevulinic acid dehydratase 著者 Xie, Y, Wang, H, Kawazoe, M, Kishishita, S, Murayama, K, Takemoto, C, Terada, T, Shirozu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-05-08 公開日 2008-05-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs To be Published
7DBL	Acyl-CoA hydrolase MpaH' mutant S139A in complex with MPA 分子名称: MYCOPHENOLIC ACID, acyl-CoA hydrolase MpaH' 著者 Li, S.Y, You, C. 登録日 2020-10-20 公開日 2021-04-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH' involved in mycophenolic acid biosynthesis. Febs J., 288, 2021
6U0J	Crosslinked Crystal Structure of Malonyl-CoA Acyl Carrier Protein Transacylase, FabD, and Acyl Carrier Protein, AcpP 分子名称: 1,2-ETHANEDIOL, Acyl carrier protein, Malonyl CoA-acyl carrier protein transacylase, ... 著者 Mindrebo, J.T, Misson, L, Davis, T.D, Burkart, M.D, Noel, J.P. 登録日 2019-08-14 公開日 2020-07-22 最終更新日 2020-10-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD. Proc.Natl.Acad.Sci.USA, 117, 2020
4V2P	Ketosynthase MxnB 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, KETOSYNTHASE, ... 著者 Koehnke, J. 登録日 2014-10-13 公開日 2015-08-26 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 In vitro reconstitution of alpha-pyrone ring formation in myxopyronin biosynthesis. Chem Sci, 6, 2015
3T8E	Crystal structure of CerJ from Streptomyces tendae soaked with CerviK 分子名称: ACETATE ION, CerJ 著者 Zocher, G, Bretschneider, T, Hertweck, C, Stehle, T. 登録日 2011-08-01 公開日 2011-12-21 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat.Chem.Biol., 8, 2011
5BNS	E. coli Fabh with small molecule inhibitor 2 分子名称: 1-{5-[2-fluoro-5-(hydroxymethyl)phenyl]pyridin-2-yl}-N-(quinolin-6-ylmethyl)piperidine-4-carboxamide, 3-oxoacyl-[acyl-carrier-protein] synthase 3 著者 Kazmirski, S.L, McKinney, D.C. 登録日 2015-05-26 公開日 2016-05-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping. Acs Infect Dis., 2, 2016
5BNM	E. coli FabH with Small Molecule Inhibitor 1 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 3, N-{[3'-(hydroxymethyl)biphenyl-4-yl]methyl}benzenesulfonamide, SULFATE ION, ... 著者 Kazmirski, S.L, McKinney, D.C. 登録日 2015-05-26 公開日 2016-05-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping. Acs Infect Dis., 2, 2016
3T6S	Crystal structure of CerJ from Streptomyces tendae in Complex with CoA 分子名称: COENZYME A, CerJ 著者 Zocher, G, Bretschneider, T, Hertweck, C, Stehle, T. 登録日 2011-07-29 公開日 2011-12-21 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat.Chem.Biol., 8, 2011
3S3L	Crystal Structure of CerJ from Streptomyces tendae 分子名称: ACETATE ION, CHLORIDE ION, CerJ 著者 Zocher, G, Hertweck, C, Bretschneider, T, Stehle, T. 登録日 2011-05-18 公開日 2011-12-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat.Chem.Biol., 8, 2011
7CPX	Lovastatin nonaketide synthase 分子名称: Lovastatin nonaketide synthase, polyketide synthase component, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Wang, J, Wang, Z. 登録日 2020-08-08 公開日 2021-01-13 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.91 Å) 主引用文献 Structural basis for the biosynthesis of lovastatin. Nat Commun, 12, 2021
3STW	Crystal Structure of tomato Methylketone Synthase I complexed with 2-tridecanone 分子名称: Methylketone synthase 1, tridec-12-en-2-one 著者 Auldridge, M.E, Austin, M.B, Noel, J.P. 登録日 2011-07-11 公開日 2012-05-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Emergent Decarboxylase Activity and Attenuation of alpha/beta-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in Tomato. Plant Cell, 24, 2012
2QJ3	Mycobacterium tuberculosis FabD 分子名称: Malonyl CoA-acyl carrier protein transacylase, NICKEL (II) ION 著者 Ghadbane, H, Brown, A.K, Kremer, L, Besra, G.S, Futterer, K. 登録日 2007-07-06 公開日 2007-09-04 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT). Acta Crystallogr.,Sect.F, 63, 2007
2FNQ	Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via A C2-like domain and a structural basis of product chirality 分子名称: Allene oxide synthase-lipoxygenase protein, CALCIUM ION, FE (II) ION 著者 Oldham, M.L, Brash, A.R, Newcomer, M.E. 登録日 2006-01-11 公開日 2006-02-28 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality. J.Biol.Chem., 280, 2005
4LS6	Crystal structure of beta-ketoacyl-ACP synthase II (FabF) I108F mutant from Bacillus subtilis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, GLYCEROL, ... 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
4LS5	Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Bacillus subtilis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, GLYCEROL, POTASSIUM ION 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
4LS7	Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a non-covalent complex with cerulenin 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Cerulenin, GLYCEROL, ... 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.674 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
3KG7	Dehydratase domain from CurH module of Curacin polyketide synthase 分子名称: CurH 著者 Akey, D.L, Smith, J.L. 登録日 2009-10-28 公開日 2010-01-19 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway. Structure, 18, 2010
3KXO	An orally active inhibitor bound at the active site of HPGDS 分子名称: 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide, GLUTATHIONE, Glutathione-requiring prostaglandin D synthase, ... 著者 Kiefer, J.R, Day, J.E, Thorarensen, A. 登録日 2009-12-03 公開日 2010-09-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of an oral potent selective inhibitor of hematopoietic prostaglandin D synthase TO BE PUBLISHED
8IZF	Cryo-EM structure of the Lac1-Lip1 (Lip1-S74F) complex 分子名称: (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Ceramide synthase LAC1, Ceramide synthase subunit LIP1 著者 Xie, T, Fang, Q, Gong, X. 登録日 2023-04-07 公開日 2023-12-13 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.85 Å) 主引用文献 Structure and mechanism of a eukaryotic ceramide synthase complex. Embo J., 42, 2023
8IZD	Cryo-EM structure of the C26-CoA-bound Lac1-Lip1 complex 分子名称: (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Ceramide synthase LAC1, Ceramide synthase subunit LIP1, ... 著者 Xie, T, Fang, Q, Gong, X. 登録日 2023-04-07 公開日 2023-12-13 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Structure and mechanism of a eukaryotic ceramide synthase complex. Embo J., 42, 2023
3KMO	Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate (Grown in the Absence of the Reducing Agent DTT) 分子名称: CALCIUM ION, ETHACRYNIC ACID, GLUTATHIONE, ... 著者 Parker, L.J. 登録日 2009-11-11 公開日 2010-03-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Diuretic drug binding to human glutathione transferase P1-1: potential role of CYS101 revealed in the double mutant C47S/Y108V To be Published
5LD8	GSK3011724A cocrystallised with Mycobacterium tuberculosis H37Rv KasA 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, SODIUM ION, TETRAETHYLENE GLYCOL, ... 著者 Chung, C.W, Neu, M. 登録日 2016-06-23 公開日 2016-09-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Identification of KasA as the cellular target of an anti-tubercular scaffold. Nat Commun, 7, 2016
6KUE	The structure of BioZ from Agrobacterium tumefaciens 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase III 著者 Ouyang, S, Hongxin, G, Sitao, Z. 登録日 2019-09-01 公開日 2020-09-02 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.992 Å) 主引用文献 Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway. Nat Commun, 12, 2021

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