3KXO

An orally active inhibitor bound at the active site of HPGDS

Summary for 3KXO

• Entry DOI: 10.2210/pdb3kxo/pdb
• Related: 2cvd 2vcx
• Descriptor: Glutathione-requiring prostaglandin D synthase, GLUTATHIONE, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide, ... (5 entities in total)
• Functional Keywords: h-pgds, pgds, hpgds, fatty acid biosynthesis, isomerase, lipid synthesis, prostaglandin biosynthesis
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : O60760
• Total number of polymer chains: 2
• Total formula weight: 48707.90

Authors

Kiefer, J.R.,Day, J.E.,Thorarensen, A. (deposition date: 2009-12-03, release date: 2010-09-01, Last modification date: 2024-02-21)

• Primary citation: Carron, C.P.,Trujillo, J.I.,Olson, K.L.,Huang, W.,Hamper, B.C.,Dice, T.,Neal, B.E.,Pelc, M.J.,Day, J.,Rohrer, D.C.,Kiefer, J.R.,Moon, J.B.,Schweitzer, B.A.,Blake, T.D.,Turner, S.R.,Woerndle, R.,Case, B.L.,Bono, C.P.,Dilworth, V.M.,Funckes-Shippy, C.L.,Hood, B.L.,Jerome, G.M.,Kornmeier, C.M.,Radabaugh, M.R.,Williams, M.L.,Davies, M.S.,Wegner, C.D.,Welsch, D.J.,Abraham, W.M.,Warren, C.J.,Dowty, M.E.,Hua, F.,Zutshi, A.,Yang, J.Z.,Thorarensen, A.; Discovery of an oral potent selective inhibitor of hematopoietic prostaglandin D synthase; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.1 Å)