PDB: 12119 件ウェブページステータス検索Chemie searchBIRD

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1BET	NEW PROTEIN FOLD REVEALED BY A 2.3 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF NERVE GROWTH FACTOR 分子名称: BETA-NERVE GROWTH FACTOR 著者 Mcdonald, N.Q, Lapatto, R, Murray-Rust, J, Gunning, J, Wlodawer, A, Blundell, T.L. 登録日 1993-04-08 公開日 1994-05-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature, 354, 1991
7B2C	Crystal structure of the ethyl-coenzyme M reductase from Candidatus Ethanoperedens thermophilum gassed with xenon 分子名称: (2R)-2-[(2S)-2-[(2S)-2-oxidanylpropoxy]propoxy]propan-1-ol, 1-THIOETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Wagner, T, Lemaire, O.N, Engilberge, S. 登録日 2020-11-26 公開日 2021-07-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of a key enzyme for anaerobic ethane activation. Science, 373, 2021
1YKI	The structure of E. coli nitroreductase bound with the antibiotic nitrofurazone 分子名称: CITRIC ACID, DIMETHYL SULFOXIDE, FLAVIN MONONUCLEOTIDE, ... 著者 Race, P.R, Lovering, A.L, Green, R.M, Ossor, A, White, S.A, Searle, P.F, Wrighton, C.J, Hyde, E.I. 登録日 2005-01-18 公開日 2005-02-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme. J.Biol.Chem., 280, 2005
5MY9	Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS935 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. 登録日 2017-01-26 公開日 2017-03-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.327 Å) 主引用文献 Structural interface between LRRK2 and 14-3-3 protein. Biochem. J., 474, 2017
5MX3	Structure of DC8E8 Fab crystallized at pH 8.5 分子名称: antibody Fab heavy chain, antibody kappa chain 著者 Skrabana, R, Novak, M, Cehlar, O, Kontsekova, E. 登録日 2017-01-20 公開日 2017-02-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Structure of DC8E8 Fab crystallized at pH 8.5 To be published
5MXX	Crystal structure of human SR protein kinase 1 (SRPK1) in complex with compound 1 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, ... 著者 Tallant, C, Redondo, C, Batson, J, Toop, H.D, Babaebi-Jadidib, R, Savitsky, P, Elkins, J.M, Newman, J.A, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bates, D.O, Morris, J.C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2017-01-25 公開日 2017-05-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12, 2017
1YCI	Factor inhibiting HIF-1 alpha in complex with N-(carboxycarbonyl)-D-phenylalanine 分子名称: FE (II) ION, Hypoxia-inducible factor 1 alpha inhibitor, N-(CARBOXYCARBONYL)-D-PHENYLALANINE, ... 著者 McDonough, M.A, Schofield, C.J. 登録日 2004-12-22 公開日 2005-05-31 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Selective inhibition of factor inhibiting hypoxia-inducible factor J.Am.Chem.Soc., 127, 2005
5MY8	Crystal structure of SRPK1 in complex with SPHINX31 分子名称: 1,2-ETHANEDIOL, CITRIC ACID, DIMETHYL SULFOXIDE, ... 著者 Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2017-01-25 公開日 2017-05-10 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12, 2017
1YEZ	Solution structure of the conserved protein from the gene locus MM1357 of Methanosarcina mazei. Northeast Structural Genomics target MaR30. 分子名称: MM1357 著者 Rossi, P, Aramini, J.M, Swapna, G.V.T, Huang, Y.P, Xiao, R, Ho, C.K, Ma, L.C, Acton, T.B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2004-12-29 公開日 2005-02-22 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of the conserved protein from the gene locus MM1357 of Methanosarcina mazei. Northeast Structural Genomics target MaR30. To be Published
5Y14	Crystal structure of LP-40/N44 分子名称: LP-40, N44 著者 Zhang, X, Wang, X, He, Y. 登録日 2017-07-19 公開日 2017-11-08 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.762 Å) 主引用文献 Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition J. Virol., 91, 2017
8DI5	Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with VH domain F6 (focused refinement of RBD and VH F6) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, VH F6 著者 Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Subramaniam, S. 登録日 2022-06-28 公開日 2022-08-24 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains. Iscience, 25, 2022
2I5S	Crystal structure of onconase with bound nucleic acid 分子名称: 5'-D(*A*(DU)P*GP*A)-3', P-30 protein 著者 Bae, E, Lee, J.E, Raines, R.T, Wesenberg, G.E, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Center for Eukaryotic Structural Genomics (CESG) 登録日 2006-08-25 公開日 2006-09-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for catalysis by onconase. J.Mol.Biol., 375, 2008
6AX8	Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate 分子名称: Methionine-tRNA ligase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate 著者 Barros-Alvarez, X, Hol, W.G.J. 登録日 2017-09-06 公開日 2018-04-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate. Acta Crystallogr F Struct Biol Commun, 74, 2018
8A4D	1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa with a thiamine analog inhibitor 分子名称: 1-deoxy-D-xylulose-5-phosphate synthase, 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]phenyl}ethanol, CALCIUM ION, ... 著者 Hamid, R, Hirsch, A. 登録日 2022-06-10 公開日 2023-07-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding. J.Biol.Chem., 299, 2023
5Y3E	Crystal structure of SARS coronavirus papain-like protease in complex with glycerol 分子名称: GLYCEROL, Replicase polyprotein 1a, SODIUM ION, ... 著者 Lin, M.H, Chou, C.Y. 登録日 2017-07-28 公開日 2018-01-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes Antiviral Res., 150, 2017
8DDI	Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166N Mutant 分子名称: 3C-like proteinase nsp5 著者 Lewandowski, E.M, Jacobs, L.M.C, Chen, Y. 登録日 2022-06-18 公開日 2022-08-31 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations. Plos Pathog., 19, 2023
8A45	Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa with 2-acetyl thiamine diphosphate 分子名称: 1-deoxy-D-xylulose-5-phosphate synthase, 2-ACETYL-THIAMINE DIPHOSPHATE, CALCIUM ION, ... 著者 Hamid, R, Hirsch, A. 登録日 2022-06-10 公開日 2023-07-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding. J.Biol.Chem., 299, 2023
8DDM	Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166R Mutant in Complex with Inhibitor GC376 分子名称: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 著者 Lewandowski, E.M, Chen, Y. 登録日 2022-06-18 公開日 2022-08-31 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations. Plos Pathog., 19, 2023
6YPG	Crystal Structure of CK2alpha with Compound 2 bound to second crystal form 分子名称: 4-[(4-naphthalen-2-yl-1,3-thiazol-2-yl)amino]-2-oxidanyl-benzoic acid, ACETATE ION, Casein kinase II subunit alpha 著者 Brear, P, Hyvonen, M. 登録日 2020-04-16 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Proposed Allosteric Inhibitors Bind to the ATP Site of CK2 alpha. J.Med.Chem., 63, 2020
8A5K	Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding 分子名称: 1-deoxy-D-xylulose-5-phosphate synthase, CALCIUM ION, GLYCEROL, ... 著者 Hamid, R, Hirsch, A. 登録日 2022-06-15 公開日 2023-07-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding. J.Biol.Chem., 299, 2023
6YPK	Crystal Structure of CK2alpha with GTP bound 分子名称: Casein kinase II subunit alpha, GUANOSINE-5'-DIPHOSPHATE 著者 Brear, P, Hyvonen, M. 登録日 2020-04-16 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Proposed Allosteric Inhibitors Bind to the ATP Site of CK2 alpha. J.Med.Chem., 63, 2020
1C4E	GURMARIN FROM GYMNEMA SYLVESTRE 分子名称: PROTEIN (GURMARIN) 著者 Fletcher, J.I, Dingley, A.J, King, G.F. 登録日 1999-07-27 公開日 1999-08-27 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide. Eur.J.Biochem., 264, 1999
1BSI	HUMAN PANCREATIC ALPHA-AMYLASE FROM PICHIA PASTORIS, GLYCOSYLATED PROTEIN 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-AMYLASE, CALCIUM ION, ... 著者 Rydberg, E.H, Sidhu, G, Vo, H.C, Hewitt, J, Cote, H.C.F, Wang, Y, Numao, S, Macgillivray, R.T.A, Overall, C.M, Brayer, G.D, Withers, S.G. 登録日 1998-08-28 公開日 1999-05-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris. Protein Sci., 8, 1999
7ZJ5	Unbound state of a brocolli-pepper aptamer FRET tile. 分子名称: POTASSIUM ION, brocolli-pepper aptamer 著者 McRae, E.K.S, Vallina, N.S, Hansen, B.K, Boussebayle, A, Andersen, E.S. 登録日 2022-04-08 公開日 2023-04-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.55 Å) 主引用文献 Structure determination of Pepper-Broccoli FRET pair by RNA origami scaffolding To Be Published
5Y4L	PRRSV nsp4 分子名称: Non-structural protein 著者 Shi, Y.J, Gang, Y, Peng, G.Q. 登録日 2017-08-04 公開日 2018-01-17 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 Identification of two antiviral inhibitors targeting 3C-like serine/3C-like protease of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus. Vet. Microbiol., 213, 2018

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