5Y3E

Crystal structure of SARS coronavirus papain-like protease in complex with glycerol

Summary for 5Y3E

• Entry DOI: 10.2210/pdb5y3e/pdb
• Descriptor: Replicase polyprotein 1a, ZINC ION, SODIUM ION, ... (5 entities in total)
• Functional Keywords: complex structure of enzyme with glycerol, hydrolase
• Biological source: Human SARS coronavirus (SARS-CoV)
• Cellular location: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
• Total number of polymer chains: 1
• Total formula weight: 36918.87

Authors

Lin, M.H.,Chou, C.Y. (deposition date: 2017-07-28, release date: 2018-01-10, Last modification date: 2023-11-22)

• Primary citation: Lin, M.H.,Moses, D.C.,Hsieh, C.H.,Cheng, S.C.,Chen, Y.H.,Sun, C.Y.,Chou, C.Y.; Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes; Antiviral Res., 150:155-163, 2017; PubMed: 29289665; DOI: 10.1016/j.antiviral.2017.12.015

Experimental method

X-RAY DIFFRACTION (1.65 Å)