8DDM

Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166R Mutant in Complex with Inhibitor GC376

Summary for 8DDM

Entry DOI	10.2210/pdb8ddm/pdb
Related	8DDI
Related PRD ID	PRD_002495
Descriptor	3C-like proteinase nsp5, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
Functional Keywords	protease, sars-cov-2, mpro, mutation, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	1
Total formula weight	34339.18
Authors	Lewandowski, E.M.,Chen, Y. (deposition date: 2022-06-18, release date: 2022-08-31, Last modification date: 2023-10-25)
Primary citation	Ou, J.,Lewandowski, E.M.,Hu, Y.,Lipinski, A.A.,Aljasser, A.,Colon-Ascanio, M.,Morgan, R.T.,Jacobs, L.M.C.,Zhang, X.,Bikowitz, M.J.,Langlais, P.R.,Tan, H.,Wang, J.,Chen, Y.,Choy, J.S. A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations. Plos Pathog., 19:e1011592-e1011592, 2023 Cited by PubMed: 37651467 DOI: 10.1371/journal.ppat.1011592 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation