2X2M
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![BU of 2x2m by Molmil](/molmil-images/mine/2x2m) | Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor | 分子名称: | (3Z)-3-[(3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Knowles, P.P, Murray-Rust, J, Kjaer, S, McDonald, N.Q. | 登録日 | 2010-01-13 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg. Med. Chem., 18, 2010
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3L94
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![BU of 3l94 by Molmil](/molmil-images/mine/3l94) | Structure of PvdQ covalently acylated with myristate | 分子名称: | 1,2-ETHANEDIOL, Acyl-homoserine lactone acylase pvdQ subunit alpha, Acyl-homoserine lactone acylase pvdQ subunit beta, ... | 著者 | Drake, E.J, Gulick, A.M. | 登録日 | 2010-01-04 | 公開日 | 2011-01-26 | 最終更新日 | 2013-04-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural characterization and high-throughput screening of inhibitors of PvdQ, an NTN hydrolase involved in pyoverdine synthesis. Acs Chem.Biol., 6, 2011
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2WM5
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![BU of 2wm5 by Molmil](/molmil-images/mine/2wm5) | X-ray structure of the substrate-free Mycobacterium tuberculosis cytochrome P450 CYP124 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 124 | 著者 | Johnston, J.B, Kells, P.M, Podust, L.M, Ortiz de Montellano, P.R. | 登録日 | 2009-06-30 | 公開日 | 2009-10-06 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A., 106, 2009
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2XJA
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![BU of 2xja by Molmil](/molmil-images/mine/2xja) | Structure of MurE from M.tuberculosis with dipeptide and ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE, ... | 著者 | Basavannacharya, C, Moody, P.R, Bhakta, S, Keep, N. | 登録日 | 2010-07-03 | 公開日 | 2010-08-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Essential Residues for the Enzyme Activity of ATP-Dependent Mure Ligase from Mycobacterium Tuberculosis. Protein Cell, 1, 2010
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3GMU
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![BU of 3gmu by Molmil](/molmil-images/mine/3gmu) | Crystal Structure of Beta-Lactamse Inhibitory Protein (BLIP) in Apo Form | 分子名称: | AMMONIUM ION, Beta-lactamase inhibitory protein, SULFATE ION | 著者 | Strynadka, N.C.J, Gretes, M, James, M.N.G. | 登録日 | 2009-03-15 | 公開日 | 2009-03-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Insights into positive and negative requirements for protein-protein interactions by crystallographic analysis of the beta-lactamase inhibitory proteins BLIP, BLIP-I, and BLP. J.Mol.Biol., 389, 2009
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3GMX
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3GSG
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![BU of 3gsg by Molmil](/molmil-images/mine/3gsg) | AmpC beta-lactamase in complex with Fragment-based Inhibitor | 分子名称: | (2S)-2-[(3aR,4R,7S,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl]propanoic acid, Beta-lactamase, DIMETHYL SULFOXIDE, ... | 著者 | Teotico, D.T, Shoichet, B.K. | 登録日 | 2009-03-26 | 公開日 | 2009-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Docking for fragment inhibitors of AmpC beta-lactamase Proc.Natl.Acad.Sci.USA, 106, 2009
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3GVQ
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![BU of 3gvq by Molmil](/molmil-images/mine/3gvq) | UROD single-chain dimer | 分子名称: | Uroporphyrinogen decarboxylase | 著者 | Hill, C.P, Phillips, J.D, Warby, C, Whitby, F.G, Kushner, J.P. | 登録日 | 2009-03-31 | 公開日 | 2009-07-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen. J.Mol.Biol., 389, 2009
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2XFS
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![BU of 2xfs by Molmil](/molmil-images/mine/2xfs) | Structural and mechanistic studies on a cephalosporin esterase from the clavulanic acid biosynthesis pathway | 分子名称: | (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, ORF12 | 著者 | Iqbal, A, Valegard, K, Kershaw, N.J, Ivison, D, Genereux, C, Dubus, A, Andersson, I, Schofield, C.J. | 登録日 | 2010-05-26 | 公開日 | 2011-06-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway. Acta Crystallogr. D Biol. Crystallogr., 69, 2013
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3GRJ
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3H6F
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3GR2
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3GSS
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![BU of 3gss by Molmil](/molmil-images/mine/3gss) | HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ETHACRYNIC ACID, GLUTATHIONE, ... | 著者 | Oakley, A.J, Rossjohn, J, Parker, M.W. | 登録日 | 1996-10-29 | 公開日 | 1997-11-12 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate. Biochemistry, 36, 1997
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2VCG
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![BU of 2vcg by Molmil](/molmil-images/mine/2vcg) | Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17 | 分子名称: | CHLORIDE ION, GLYCEROL, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ... | 著者 | Dickmanns, A, Strasser, A, Ficner, R. | 登録日 | 2007-09-24 | 公開日 | 2008-01-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Phenylalanine-Containing Hydroxamic Acids as Selective Inhibitors of Class Iib Histone Deacetylases (Hdacs). Bioorg.Med.Chem., 16, 2008
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3H4K
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![BU of 3h4k by Molmil](/molmil-images/mine/3h4k) | Crystal structure of the wild type Thioredoxin glutatione reductase from Schistosoma mansoni in complex with auranofin | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GOLD ION, ... | 著者 | Angelucci, F, Dimastrogiovanni, D, Miele, A.E, Boumis, G, Brunori, M, Bellelli, A. | 登録日 | 2009-04-20 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J.Biol.Chem., 284, 2009
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2W5A
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![BU of 2w5a by Molmil](/molmil-images/mine/2w5a) | Human Nek2 kinase ADP-bound | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Westwood, I, Bayliss, R. | 登録日 | 2008-12-08 | 公開日 | 2008-12-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Insights Into the Conformational Variability and Regulation of Human Nek2 Kinase. J.Mol.Biol., 386, 2009
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3LNX
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![BU of 3lnx by Molmil](/molmil-images/mine/3lnx) | Second PDZ domain from human PTP1E | 分子名称: | IODIDE ION, THIOCYANATE ION, Tyrosine-protein phosphatase non-receptor type 13 | 著者 | Zhang, J, Chang, A, Ke, H, Phillips Jr, G.N, Lee, A.L, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2010-02-03 | 公開日 | 2010-02-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.642 Å) | 主引用文献 | Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry, 49, 2010
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3DKC
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![BU of 3dkc by Molmil](/molmil-images/mine/3dkc) | Structure of MET receptor tyrosine kinase in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Hepatocyte growth factor receptor, ... | 著者 | Hendle, J. | 登録日 | 2008-06-24 | 公開日 | 2009-07-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer Ther., 8, 2009
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2WD6
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3E0L
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![BU of 3e0l by Molmil](/molmil-images/mine/3e0l) | Computationally Designed Ammelide Deaminase | 分子名称: | Guanine deaminase, ZINC ION | 著者 | Murphy, P.M, Bolduc, J.M, Gallaher, J.L, Stoddard, B.L, Baker, D. | 登録日 | 2008-07-31 | 公開日 | 2009-03-03 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Alteration of enzyme specificity by computational loop remodeling and design. Proc.Natl.Acad.Sci.USA, 106, 2009
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3GOY
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![BU of 3goy by Molmil](/molmil-images/mine/3goy) | Crystal structure of human poly(adp-ribose) polymerase 14, catalytic fragment in complex with an inhibitor 3-aminobenzamide | 分子名称: | 3-aminobenzamide, Poly [ADP-ribose] polymerase 14 | 著者 | Karlberg, T, Moche, M, Lehtio, L, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Schutz, P, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC) | 登録日 | 2009-03-20 | 公開日 | 2009-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors. Nat.Biotechnol., 30, 2012
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2W3N
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![BU of 2w3n by Molmil](/molmil-images/mine/2w3n) | Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans | 分子名称: | ACETATE ION, CARBONIC ANHYDRASE 2, GLYCEROL, ... | 著者 | Schlicker, C, Hall, R.A, Vullo, D, Middelhaufe, S, Gertz, M, Supuran, C.T, Muehlschlegel, F.A, Steegborn, C. | 登録日 | 2008-11-13 | 公開日 | 2008-12-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans. J. Mol. Biol., 385, 2009
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2W6G
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![BU of 2w6g by Molmil](/molmil-images/mine/2w6g) | Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration: Hydration State 3. | 分子名称: | ATP SYNTHASE SUBUNIT ALPHA HEART ISOFORM, MITOCHONDRIAL, ATP SYNTHASE SUBUNIT BETA, ... | 著者 | Sanchez-Weatherby, J, Felisaz, F, Gobbo, A, Huet, J, Ravelli, R.B.G, Bowler, M.W, Cipriani, F. | 登録日 | 2008-12-18 | 公開日 | 2009-10-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (6 Å) | 主引用文献 | Improving Diffraction by Humidity Control: A Novel Device Compatible with X-Ray Beamlines. Acta Crystallogr.,Sect.D, 65, 2009
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3GQZ
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3KO9
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![BU of 3ko9 by Molmil](/molmil-images/mine/3ko9) | |