2W3N

Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans

Summary for 2W3N

Entry DOI	10.2210/pdb2w3n/pdb
Descriptor	CARBONIC ANHYDRASE 2, ZINC ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	beta-class carbonic anhydrase, lyase, inhibition, sulfonamide, cryptococcus neoformans
Biological source	CRYPTOCOCCUS NEOFORMANS
Total number of polymer chains	3
Total formula weight	80359.01
Authors	Schlicker, C.,Hall, R.A.,Vullo, D.,Middelhaufe, S.,Gertz, M.,Supuran, C.T.,Muehlschlegel, F.A.,Steegborn, C. (deposition date: 2008-11-13, release date: 2008-12-30, Last modification date: 2023-12-13)
Primary citation	Schlicker, C.,Hall, R.A.,Vullo, D.,Middelhaufe, S.,Gertz, M.,Supuran, C.T.,Muhlschlegel, F.A.,Steegborn, C. Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans. J. Mol. Biol., 385:1207-1220, 2009 Cited by PubMed: 19071134 DOI: 10.1016/j.jmb.2008.11.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation