2W3N
Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004089 | molecular_function | carbonate dehydratase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016829 | molecular_function | lyase activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071244 | biological_process | cellular response to carbon dioxide |
| B | 0004089 | molecular_function | carbonate dehydratase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016829 | molecular_function | lyase activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0071244 | biological_process | cellular response to carbon dioxide |
| C | 0004089 | molecular_function | carbonate dehydratase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016829 | molecular_function | lyase activity |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0071244 | biological_process | cellular response to carbon dioxide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1232 |
| Chain | Residue |
| A | CYS68 |
| A | HIS124 |
| A | CYS127 |
| A | ACT1233 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B1234 |
| Chain | Residue |
| B | CYS68 |
| B | HIS124 |
| B | CYS127 |
| B | ACT1235 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C1232 |
| Chain | Residue |
| C | HIS124 |
| C | CYS127 |
| C | ACT1233 |
| C | CYS68 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ACT A1233 |
| Chain | Residue |
| A | GLN59 |
| A | CYS68 |
| A | ASP70 |
| A | TYR109 |
| A | HIS124 |
| A | GLY126 |
| A | CYS127 |
| A | GLY128 |
| A | GLY129 |
| A | ZN1232 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ACT B1235 |
| Chain | Residue |
| B | CYS68 |
| B | ASP70 |
| B | HIS124 |
| B | CYS127 |
| B | GLY128 |
| B | GLY129 |
| B | ZN1234 |
| C | GLN59 |
| C | PHE87 |
| C | TYR109 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT C1233 |
| Chain | Residue |
| B | GLN59 |
| C | CYS68 |
| C | ASP70 |
| C | HIS124 |
| C | CYS127 |
| C | GLY128 |
| C | GLY129 |
| C | ZN1232 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A1234 |
| Chain | Residue |
| A | LYS97 |
| A | ASP101 |
| A | SER102 |
| A | TYR152 |
| A | HOH2031 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| A | ARG72 | |
| A | ASP70 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| B | ARG72 | |
| B | ASP70 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| C | ARG72 | |
| C | ASP70 |
