3H4K

Crystal structure of the wild type Thioredoxin glutatione reductase from Schistosoma mansoni in complex with auranofin

Summary for 3H4K

Entry DOI	10.2210/pdb3h4k/pdb
Related	2v6o
Descriptor	Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE, GOLD ION, ... (7 entities in total)
Functional Keywords	schistosoma mansoni, gold, auranofin, glutathione, fad, flavoprotein, oxidoreductase, redox-active center
Biological source	Schistosoma mansoni (Blood fluke)
Total number of polymer chains	1
Total formula weight	67219.37
Authors	Angelucci, F.,Dimastrogiovanni, D.,Miele, A.E.,Boumis, G.,Brunori, M.,Bellelli, A. (deposition date: 2009-04-20, release date: 2009-08-25, Last modification date: 2023-11-01)
Primary citation	Angelucci, F.,Sayed, A.A.,Williams, D.L.,Boumis, G.,Brunori, M.,Dimastrogiovanni, D.,Miele, A.E.,Pauly, F.,Bellelli, A. Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J.Biol.Chem., 284:28977-28985, 2009 Cited by PubMed: 19710012 DOI: 10.1074/jbc.M109.020701 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation