Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD A 599 |
| Chain | Residue |
| A | GLY114 |
| A | GLY158 |
| A | CYS159 |
| A | LYS162 |
| A | ALA226 |
| A | LYS227 |
| A | GLY228 |
| A | ALA256 |
| A | THR257 |
| A | GLY258 |
| A | TYR296 |
| A | GLY116 |
| A | ARG393 |
| A | VAL400 |
| A | GLY432 |
| A | ASP433 |
| A | GLN440 |
| A | LEU441 |
| A | THR442 |
| A | PRO443 |
| A | HIS571 |
| A | HOH612 |
| A | SER117 |
| A | HOH616 |
| A | HOH631 |
| A | HOH633 |
| A | HOH637 |
| A | HOH646 |
| A | GLY118 |
| A | ASP137 |
| A | TYR138 |
| A | GLY152 |
| A | THR153 |
| A | CYS154 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE AU A 600 |
| Chain | Residue |
| A | PHE505 |
| A | PRO507 |
| A | CYS520 |
| A | CYS574 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE AU A 601 |
| Chain | Residue |
| A | CYS154 |
| A | CYS159 |
| A | THR442 |
| A | HIS571 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU A 602 |
| Chain | Residue |
| A | SER295 |
| A | GLY392 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GSH A 604 |
| Chain | Residue |
| A | LYS25 |
| A | CYS28 |
| A | GLN60 |
| A | THR71 |
| A | VAL72 |
| A | ASP84 |
| A | SER85 |
| A | GLN86 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PG4 A 605 |
| Chain | Residue |
| A | SER318 |
| A | ILE319 |
| A | LEU320 |
| A | GLN326 |
| A | ALA329 |
| A | GLY333 |
| A | ASP334 |
| A | GLU337 |
| A | LYS345 |
| A | HOH608 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PG4 A 606 |
| Chain | Residue |
| A | TRP10 |
| A | LYS13 |
| A | THR14 |
| A | SER17 |
| A | ASP420 |
| A | TYR429 |
| A | ARG455 |
| A | LEU456 |
| A | ALA460 |
| A | THR461 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
| Chain | Residue | Details |
| A | GLY151-PRO161 | |
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. VIlFSktTCPYCKkVkdvL |
| Chain | Residue | Details |
| A | VAL20-LEU38 | |
| site_id | PS00195 |
| Number of Residues | 17 |
| Details | GLUTAREDOXIN_1 Glutaredoxin active site. LFskttCPYCkkVkdvL |
| Chain | Residue | Details |
| A | LEU22-LEU38 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS154 | |
| A | CYS159 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | GLU576 | |
| A | HIS571 | |
